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. 1991 Mar;54(3):217–222. doi: 10.1136/jnnp.54.3.217

Normal P300 following extensive damage to the left medial temporal lobe.

M D Rugg 1, C D Pickles 1, D D Potter 1, R C Roberts 1
PMCID: PMC1014388  PMID: 2030348

Abstract

Event-related potentials (ERPs) were recorded during auditory and visual "oddball" tasks from a patient with a severe verbal memory deficit due to a low grade infiltrating glioma which involved the full extent of the left medial temporal lobe. In both sensory modalities, the patient's oddball-evoked P300s were symmetrical and of normal amplitude. These findings are difficult to reconcile with the hypothesis that the hippocampus, or any other medial temporal structure, makes a substantial contribution to the scalp P300.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Awad I. A., Katz A., Hahn J. F., Kong A. K., Ahl J., Lüders H. Extent of resection in temporal lobectomy for epilepsy. I. Interobserver analysis and correlation with seizure outcome. Epilepsia. 1989 Nov-Dec;30(6):756–762. doi: 10.1111/j.1528-1157.1989.tb05335.x. [DOI] [PubMed] [Google Scholar]
  2. Duncan-Johnson C. C., Donchin E. On quantifying surprise: the variation of event-related potentials with subjective probability. Psychophysiology. 1977 Sep;14(5):456–467. doi: 10.1111/j.1469-8986.1977.tb01312.x. [DOI] [PubMed] [Google Scholar]
  3. Halgren E., Squires N. K., Wilson C. L., Rohrbaugh J. W., Babb T. L., Crandall P. H. Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events. Science. 1980 Nov 14;210(4471):803–805. doi: 10.1126/science.7434000. [DOI] [PubMed] [Google Scholar]
  4. Johnson R., Jr Scalp-recorded P300 activity in patients following unilateral temporal lobectomy. Brain. 1988 Dec;111(Pt 6):1517–1529. doi: 10.1093/brain/111.6.1517. [DOI] [PubMed] [Google Scholar]
  5. Knight R. T., Scabini D., Woods D. L., Clayworth C. C. Contributions of temporal-parietal junction to the human auditory P3. Brain Res. 1989 Nov 13;502(1):109–116. doi: 10.1016/0006-8993(89)90466-6. [DOI] [PubMed] [Google Scholar]
  6. McCarthy G., Wood C. C., Williamson P. D., Spencer D. D. Task-dependent field potentials in human hippocampal formation. J Neurosci. 1989 Dec;9(12):4253–4268. doi: 10.1523/JNEUROSCI.09-12-04253.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Meador K. J., Loring D. W., King D. W., Gallagher B. B., Gould M. J., Flanigin H. F., Smith J. R. Limbic evoked potentials predict site of epileptic focus. Neurology. 1987 Mar;37(3):494–497. doi: 10.1212/wnl.37.3.494. [DOI] [PubMed] [Google Scholar]
  8. Paller K. A., Zola-Morgan S., Squire L. R., Hillyard S. A. P3-like brain waves in normal monkeys and in monkeys with medial temporal lesions. Behav Neurosci. 1988 Oct;102(5):714–725. doi: 10.1037//0735-7044.102.5.714. [DOI] [PubMed] [Google Scholar]
  9. Puce A., Kalnins R. M., Berkovic S. F., Donnan G. A., Bladin P. F. Limbic P3 potentials, seizure localization, and surgical pathology in temporal lobe epilepsy. Ann Neurol. 1989 Sep;26(3):377–385. doi: 10.1002/ana.410260311. [DOI] [PubMed] [Google Scholar]
  10. STEPHENSON W. A., GIBBS F. A. A balanced non-cephalic reference electrode. Electroencephalogr Clin Neurophysiol. 1951 May;3(2):237–240. doi: 10.1016/0013-4694(51)90017-x. [DOI] [PubMed] [Google Scholar]
  11. Semlitsch H. V., Anderer P., Schuster P., Presslich O. A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology. 1986 Nov;23(6):695–703. doi: 10.1111/j.1469-8986.1986.tb00696.x. [DOI] [PubMed] [Google Scholar]
  12. Stapleton J. M., Halgren E. Endogenous potentials evoked in simple cognitive tasks: depth components and task correlates. Electroencephalogr Clin Neurophysiol. 1987 Jul;67(1):44–52. doi: 10.1016/0013-4694(87)90162-3. [DOI] [PubMed] [Google Scholar]
  13. Stapleton J. M., Halgren E., Moreno K. A. Endogenous potentials after anterior temporal lobectomy. Neuropsychologia. 1987;25(3):549–557. doi: 10.1016/0028-3932(87)90079-0. [DOI] [PubMed] [Google Scholar]
  14. von Cramon D. Y., Hebel N., Schuri U. Verbal memory and learning in unilateral posterior cerebral infarction. A report on 30 cases. Brain. 1988 Oct;111(Pt 5):1061–1077. doi: 10.1093/brain/111.5.1061. [DOI] [PubMed] [Google Scholar]

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