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. 1991 Aug;54(8):679–682. doi: 10.1136/jnnp.54.8.679

Glutathione peroxidase in early and advanced Parkinson's disease.

P Johannsen 1, G Velander 1, J Mai 1, E B Thorling 1, E Dupont 1
PMCID: PMC1014468  PMID: 1940936

Abstract

A defective antioxidant scavenging system plays a major role in one of the theories of the pathogenesis of Parkinson's disease. The aim of this study was to investigate whether there is a general difference in antioxidant activity between early and advanced cases of Parkinson's disease. Twenty five recently diagnosed patients, without any clinical fluctuations (group A), and 25 patients in a late phase of the disease with severe fluctuations in response to levodopa therapy (group B) were included in the study. Erythrocyte glutathione peroxidase was determined as a measure of antioxidant activity and significantly lower values were found in group B than in group A. Regression analyses in groups A and B showed significant correlation between glutathione peroxidase and duration of disease, but not between glutathione peroxidase and age of patients.

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Selected References

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