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(a) An LNP with high Tm lipid represented by red head-group lipid keeps the drug cargo intact. (b) An LNP with low Tm lipid with a shorter carbon chain represented by blue head-group lipid and (c) An LNP with low Tm lipid with unsaturation represented by green head-group lipid. Both (b) and (c) impart more fluidic character to the LNP and thereby allow for more leakage of cargo from LNPs.
