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. 2023 Apr 7;15(4):1184. doi: 10.3390/pharmaceutics15041184

Table 3.

Commonly used pH-sensitive linkers and their structures.

pH-Sensitive Linker Chemical Structure
Trans-2-aminocylohexenol (TACH) graphic file with name pharmaceutics-15-01184-i004.jpg
Acetal Group graphic file with name pharmaceutics-15-01184-i005.jpg
Vinyl Ether Group graphic file with name pharmaceutics-15-01184-i006.jpg
Ortho ester Group graphic file with name pharmaceutics-15-01184-i007.jpg
Hydrazone Group graphic file with name pharmaceutics-15-01184-i008.jpg