Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1991 Sep;54(9):783–786. doi: 10.1136/jnnp.54.9.783

Cognition and cerebral blood flow in lateralised parkinsonism: lack of functional lateral asymmetries.

A Agniel 1, P Celsis 1, G Viallard 1, J L Montastruc 1, O Rascol 1, J F Demonet 1, J P Marc-Vergnes 1, A Rascol 1
PMCID: PMC1014516  PMID: 1955895

Abstract

Cognitive and cerebral blood flow (CBF) lateral asymmetries have been quantified in 23 right handed patients with lateralised idiopathic Parkinson's disease. Thirteen patients who had predominant right-sided symptoms (RPD) were compared with ten who had predominant left-sided symptoms (LPD). The patient subgroups were matched for age, education, duration of illness, disease severity and medication. Normalised asymmetries scores were calculated from the data obtained with a test battery and SPECT. No correlation was found between laterality of motor Parkinsonian symptoms and cognitive or haemodynamic asymmetry scores.

Full text

PDF

Images in this article

786Image
on p.786

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bentin S., Silverberg R., Gordon H. W. Asymmetrical cognitive deterioration in demented and Parkinson patients. Cortex. 1981 Dec;17(4):533–543. doi: 10.1016/s0010-9452(81)80060-3. [DOI] [PubMed] [Google Scholar]
  2. Blonder L. X., Gur R. E., Gur R. C., Saykin A. J., Hurtig H. I. Neuropsychological functioning in hemiparkinsonism. Brain Cogn. 1989 Mar;9(2):244–257. doi: 10.1016/0278-2626(89)90034-1. [DOI] [PubMed] [Google Scholar]
  3. Boller F., Mizutani T., Roessmann U., Gambetti P. Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations. Ann Neurol. 1980 Apr;7(4):329–335. doi: 10.1002/ana.410070408. [DOI] [PubMed] [Google Scholar]
  4. Boller F., Passafiume D., Keefe N. C., Rogers K., Morrow L., Kim Y. Visuospatial impairment in Parkinson's disease. Role of perceptual and motor factors. Arch Neurol. 1984 May;41(5):485–490. doi: 10.1001/archneur.1984.04050170031011. [DOI] [PubMed] [Google Scholar]
  5. Brown R. G., Marsden C. D. Cognitive function in Parkinson's disease: from description to theory. Trends Neurosci. 1990 Jan;13(1):21–29. doi: 10.1016/0166-2236(90)90058-i. [DOI] [PubMed] [Google Scholar]
  6. Celsis P., Agniel A., Puel M., Le Tinnier A., Viallard G., Démonet J. F., Rascol A., Marc-Vergnes J. P. Lateral asymmetries in primary degenerative dementia of the Alzheimer type. A correlative study of cognitive, haemodynamic and EEG data, in relation with severity, age of onset and sex. Cortex. 1990 Dec;26(4):585–596. doi: 10.1016/s0010-9452(13)80308-5. [DOI] [PubMed] [Google Scholar]
  7. Celsis P., Agniel A., Puel M., Rascol A., Marc-Vergnes J. P. Focal cerebral hypoperfusion and selective cognitive deficit in dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1602–1612. doi: 10.1136/jnnp.50.12.1602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Celsis P., Goldman T., Henriksen L., Lassen N. A. A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations. J Comput Assist Tomogr. 1981 Oct;5(5):641–645. doi: 10.1097/00004728-198110000-00006. [DOI] [PubMed] [Google Scholar]
  9. Direnfeld L. K., Albert M. L., Volicer L., Langlais P. J., Marquis J., Kaplan E. Parkinson's disease. The possible relationship of laterality to dementia and neurochemical findings. Arch Neurol. 1984 Sep;41(9):935–941. doi: 10.1001/archneur.1984.04050200041016. [DOI] [PubMed] [Google Scholar]
  10. Dubois B., Hauw J. J., Ruberg M., Serdaru M., Javoy-Agid F., Agid Y. Démence et maladie de Parkinson: corrélations biochimiques et anatomo-cliniques. Rev Neurol (Paris) 1985;141(3):184–193. [PubMed] [Google Scholar]
  11. Garnett E. S., Nahmias C., Firnau G. Central dopaminergic pathways in hemiparkinsonism examined by positron emission tomography. Can J Neurol Sci. 1984 Feb;11(1 Suppl):174–179. doi: 10.1017/s0317167100046369. [DOI] [PubMed] [Google Scholar]
  12. Hansen L., Salmon D., Galasko D., Masliah E., Katzman R., DeTeresa R., Thal L., Pay M. M., Hofstetter R., Klauber M. The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology. 1990 Jan;40(1):1–8. doi: 10.1212/wnl.40.1.1. [DOI] [PubMed] [Google Scholar]
  13. Henriksen L., Boas J. Regional cerebral blood flow in hemiparkinsonian patients. Emission computerized tomography of inhaled 133Xenon before and after levodopa. Acta Neurol Scand. 1985 Apr;71(4):257–266. doi: 10.1111/j.1600-0404.1985.tb03198.x. [DOI] [PubMed] [Google Scholar]
  14. Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427–442. doi: 10.1212/wnl.17.5.427. [DOI] [PubMed] [Google Scholar]
  15. Huber S. J., Freidenberg D. L., Shuttleworth E. C., Paulson G. W., Clapp L. E. Neuropsychological similarities in lateralized parkinsonism. Cortex. 1989 Sep;25(3):461–470. doi: 10.1016/s0010-9452(89)80059-0. [DOI] [PubMed] [Google Scholar]
  16. Lees A. J., Smith E. Cognitive deficits in the early stages of Parkinson's disease. Brain. 1983 Jun;106(Pt 2):257–270. doi: 10.1093/brain/106.2.257. [DOI] [PubMed] [Google Scholar]
  17. Montastruc J. L., Celsis P., Agniel A., Demonet J. F., Doyon B., Puel M., Marc-Vergnes J. P., Rascol A. Levodopa-induced regional cerebral blood flow changes in normal volunteers and patients with Parkinson's disease. Lack of correlation with clinical or neuropsychological improvements. Mov Disord. 1987;2(4):279–289. doi: 10.1002/mds.870020405. [DOI] [PubMed] [Google Scholar]
  18. Oyebode J. R., Barker W. A., Blessed G., Dick D. J., Britton P. G. Cognitive functioning in Parkinson's disease: in relation to prevalence of dementia and psychiatric diagnosis. Br J Psychiatry. 1986 Dec;149:720–725. doi: 10.1192/bjp.149.6.720. [DOI] [PubMed] [Google Scholar]
  19. Perlmutter J. S., Raichle M. E. Regional blood flow in hemiparkinsonism. Neurology. 1985 Aug;35(8):1127–1134. doi: 10.1212/wnl.35.8.1127. [DOI] [PubMed] [Google Scholar]
  20. Rascol O., Montastruc J. L., Senard J. M., Demonet J. F., Simonetta M., Rascol A. Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in parkinsonian patients: a double-blind cross-over placebo-controlled trial. Neurology. 1988 Sep;38(9):1387–1391. doi: 10.1212/wnl.38.9.1387. [DOI] [PubMed] [Google Scholar]
  21. Rutgers A. W., Lakke J. P., Paans A. M., Vaalburg W., Korf J. Tracing of dopamine receptors in hemiparkinsonism with positron emission tomography (PET). J Neurol Sci. 1987 Sep;80(2-3):237–248. doi: 10.1016/0022-510x(87)90158-4. [DOI] [PubMed] [Google Scholar]
  22. Spicer K. B., Roberts R. J., LeWitt P. A. Neuropsychological performance in lateralized parkinsonism. Arch Neurol. 1988 Apr;45(4):429–432. doi: 10.1001/archneur.1988.00520280079019. [DOI] [PubMed] [Google Scholar]
  23. Starkstein S., Leiguarda R., Gershanik O., Berthier M. Neuropsychological disturbances in hemiparkinson's disease. Neurology. 1987 Nov;37(11):1762–1764. doi: 10.1212/wnl.37.11.1762. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES