Introduction
Home healthcare (HHC), which is defined as skilled healthcare that is provided to an individual in their own home environment, is one of the fastest-growing segments of the healthcare industry in the United States (U.S)1. Approximately 5 million U.S. adults are currently receiving HHC, and the demand is expected to grow over the next few years2. With the shift in healthcare delivery from hospitals to the community due to increasing patient ages, shorter hospital stays, and improved health technology3, an increasing number of patients with complex medical conditions rely on HHC after being discharged from an acute care setting4, 5. These changes in healthcare delivery have led to discussions about patient safety in HHC, including efforts to reduce acute care utilization (i.e., unplanned hospitalizations or emergency department (ED) visits)2, 6. In spite of several national and local quality improvement efforts focused on acute and chronic ambulatory care sensitive conditions (i.e. health conditions for which adequate management, treatment, and interventions delivered in the ambulatory care setting could potentially prevent hospitalizations)7, approximately one in five patients still experience hospitalizations or ED visits during HHC services. There has not been a significant reduction in these occurrences over the past decade8, 9. With up to 30% of hospitalizations or ED visits deemed as potentially preventable10, further efforts (such as identifying patients at risk and implementing risk mitigation strategies in a timely manner) may prevent these negative outcomes11.
As data science methods are evolving, the use of cutting-edge data science technologies is gaining attention for identifying patients at risk and enhancing the predictive ability of risk prediction models. In addition, verbal communication between healthcare providers and patients are increasingly recognized as valuable informational resources because they involve information-seeking and sharing behaviors and often include extensive information12. Thus, as part of the trend, using artificial intelligence techniques developed for extracting insights from patient-nurse verbal communication (e.g., speech recognition) may be used to enhance risk identification13. Several recent studies used audio-recorded encounters between patients and health providers to predict further health outcomes. For example, one study applied machine learning to successfully predict the presence of post-traumatic stress disorder based on recorded communications between psychologists and army veterans14. Another study used the content of military couples’ communications to predict risk for suicide15. However, despite that active verbal communications, including medical history taking, nursing assessments, and problem-focused discussions, take place between patients and HHC nurses during home visits, this has not been studied previously, nor have natural language processing (NLP) methods been applied to these verbal communications.
Converting speech to text is the first step in exploring the contents of verbal communication. The process of automatic speech recognition is a way for voice technology to recognize spoken sounds as words16. In this technology, computers can interact with humans in the most natural way using spoken interactions that combine voice and text techniques as a form of NLP. Over the past few years, speech recognition accuracy has increased as a result of advances in deep learning17. Even though automatic speech-to-text systems are becoming more prevalent, and they can even be found in toys, smartphones, and other devices with voice assistance, they have not yet been widely adopted in healthcare, especially in HHC to enable an analysis of verbal communication. Due to its significant potential to assist healthcare providers in analyzing verbal data by saving time and effort from manually generating transcripts and enabling real-time transcription, auto-generated transcripts, including their efficiency and accuracy, should be evaluated to determine if they can replace human-generated transcripts.
To summarize, there have been no studies that have applied NLP to verbal communication between nurses and patients, nor have auto-generated transcripts been evaluated for the feasibility of replacing human-generated transcripts to improve patient risk identification. To address these knowledge gaps, the purpose of this study was (1) to refine the NLP algorithm that was developed by our team to identify terms associated with risk for hospitalizations or ED visits from clinical narrative notes in order for the algorithm to be applied to patient-nurse verbal communication in HHC; and (2) to compare the performances of NLP algorithms on auto-generated transcripts with human-generated transcripts in patient-nurse verbal communication.
Methods
This retrospective cohort pilot study utilized information derived from patient-nurse verbal communications. In addition, sociodemographic and structured clinical assessment data (i.e., routine clinical assessment data called the Outcome and Assessment Information Set [OASIS] that is a federally mandated assessment in HHC, and administrative records) were extracted from electronic health records (EHRs) of a large HHC agency. Figure 1 provides a general overview of the study methods. The study was approved by the Institutional Review Boards of the participating institutions.
Study Population
We collected data from the largest non-profit HHC organization in the Northeastern U.S. between 2/16/2021 and 9/2/2021. Informed consent was obtained from all patients and nurses before their participation in the study. Nurses were recruited through email outreach to the participating HHC organization. After explaining the purpose, risks, and benefits of the study, our research assistant (employed by the study agency) obtained a written consent from those who agree to participate. Afterwards, the nurses were instructed on how to use the audio recording devices to record patient-nurse verbal communications. To recruit participating patients, the research assistant explained the purpose, risks, and benefits of the study over the phone prior to the nurse visit Once the patient verbally consented, a consent form was mailed for the patient’s record. As a token of appreciation for their participation, patients and nurses received gift cards. More information on how the participants were recruited can be found elsewhere18,19.
Verbal Communications
In the study, five nurses recorded 127 patient-nurse visits with 44 patients using two audio recording devices (Saramonic Blink500 Pro B2 Pro and Sony ICD-TX6). We selected these two devices based on their high rating for functionality and usability compared to other audio recorders. Further details about the evaluation of the devices’ functionality and usability were presented in our previous study19.
For this analysis, we aimed to generate a maximum variation sample of the recordings. To accomplish that, we assessed each recording for information richness (i.e., verbal communication in which at least four health problems were discussed) and recording quality (i.e., recordings that had minimal background noise, echo, or interruptions). Consequently, a total of 22 recordings representing 15 patients were selected. A detailed description has been provided in our previous study18.
Converting Speech to Text: Human-generated Transcripts
The selected audio recordings were transcribed verbatim by a human expert transcriber using TranscribeMe, a HIPAA-compliant transcription services company (https://www.transcribeme.com). The transcripts included speaker information (e.g., speaker 1, speaker 2), timestamps, and content at the utterance level (i.e., the smallest unit of speech ending and beginning with a clear pause). Based on listening to audio recordings and reviewing transcript content, the authors identified and marked the speaker’s role in transcripts (e.g., patient, nurse). To evaluate the accuracy of the human-generated transcripts of patient-nurse verbal communication, 500 utterances of communication were randomly selected and the author (JS) reviewed each utterance based on the time stamps attached to every utterance to ensure the quality of human-transcripts.
Converting Speech to Text: Auto-generated Transcripts
We created auto-generated transcripts for selected audio recordings using the Amazon Transcribe Medical service (https://aws.amazon.com/transcribe/medical/), which is tailored for medical professionals who need to transcribe medically-related speech such as physician dictation, drug safety monitoring, and clinician-patient communications. Transcripts included speaker information (e.g., speaker 1, speaker 2), timestamps (i.e., start and end time), and content (transcription) of verbal communication for each speaker20. To evaluate the accuracy, the word error rate (WER), a metric commonly used to evaluate speech recognition systems, was calculated against the human-generated transcripts by co-authors (MZ, SV)19. In the WER, transcription errors are calculated by substitution errors (such that the identification system incorrectly recognizes one word for another), deletion errors (such that the recognition system missed words), and insertion errors (such that words are introduced into the generated text by the recognition system) with refence to the total word in the transription21.
Natural Language Processing (NLP) algorithm
Following sections describe our previously developed rule-based NLP algorithm22 and its refinement to process verbal communications. We used both nurses’ and patients’ utterances to identify the risk factors using the NLP algorithm since nurses’ utterances can indicate signs and symptoms by describing their observations or educating them on the signs and symptoms as an intervention.
A. NLP Algorithm Development
(1) Identifying factors associated with hospitalizations or ED visits using Omaha System
Our research team previously identified factors associated with hospitalizations or ED visits among HHC patients by assembling a team of experts in nursing, HHC and informatics22. To generate a list of risk factors, we used the Omaha System problems, which is - a commonly used standard terminology for documenting clinical information among community-based care (https://www.omahasystem.org/)23. The Omaha System comprehensively covers environmental, psychosocial, physiological and health related behavior problem domains23. The experts determined that a subset of 31 out of 42 Omaha System problems (e.g., “Circulation”, “Pain”, “Medication regimen”) with 160 sign/symptoms (e.g., sign/symptoms of ‘edema’ or ‘discoloration of skin or cyanosis’ under “Circulation” problem, or sign/symptoms of ‘expresses discomfort or pain’ or ‘compensated movement or guarding’ under “Pain” problem) could be considered as risk factors for hospitalizations or ED visits in HHC. See our prior publication for a complete list of risk factors22.
(2) Creating preliminary list of terms for risk factors using a vocabulary of standardized terminology
The common approach is to first map narrative clinical notes to concepts from biomedical knowledge sources of standardized terminology like Unified Medical Language System [UMLS]24, which provides a richer set of concurrent concepts to integrate documents that contain related concepts25, 26. Thus, our team developed a comprehensive lexicon on each risk factor with synonyms from a standardized medical terminology database (i.e., UMLS). For example, for the problem of “pain”, we identified UMLS synonyms such as “express discomfort,” “express pain,” or “aches.”
(3) Creating language model: word embedding model (Word2Vec)
In this study, we used publicly available NimbleMiner NLP software (http://github.com/mtopaz/NimbleMiner)27. As a part of the tools used in the software, Word embedding (Word2Vec) was used. It is a language model that generates statistical representations of texts that learns to identify synonyms for terms of interest relevant to a specific domain by analyzing word associations28. To prepare clinical notes for the word embedding model training, the notes were pre-processed to remove punctuation and to lowercase all letters29. Next, it created an embedding vector for each clinical note with a maximum word length of four (4-grams)29 before applying a skip-gram model that is a generalization of n-grams that doesn’t require that the components of the text under consideration be consecutive but may skip over gaps30. Using this approach, we identified synonyms for risk factors in a large collection of HHC clinical notes (n = approximately 2.3 million) and terms used in patient-nurse verbal communication (n = 5,118 utterances).
(4) Implementing an interactive rapid vocabulary explorer
As part of the NimbleMiner software, two authors who are experts in HHC and informatics (JS, MT) implemented an interactive rapid vocabulary explorer to discover large vocabularies of relevant terms and expressions. The interactive rapid vocabulary explorer allowed us to develop an expanded list of synonymous expressions based on pre-populated lists of synonyms extracted from the UMLS. When the user enters a query term of interest (e.g., the problem of “Skin”), the system returns a list of similar terms it identified as relevant (e.g., “wound,” “wound noted,” “wd,” “ulcer”) based on cosine similarity metric. The user selects and saves relevant terms by clicking on them until no further relevant terms appear on the user interface. Negated terms (e.g., “denies,” “no,” “not,” “ruled out”) or other irrelevant terms not selected by the user were used for further processing, such as negation detection to distinguish and exclude negated terms.
(5) Label assignment and review
An NLP algorithm assigned labels to transcripts of patient-nurse verbal communications using terms that have been selected and saved (while excluding notes with negations and other irrelevant terms). Assigning a “positive label” means that a risk factor of interest is present in the transcripts. The users reviewed the assigned labels for accuracy.
B. NLP Algorithm Validation
To test whether the NLP algorithm was able to identify risk factors as accurately as a clinical expert, we employed “gold standard” testing methods. A total of 5,118 utterances from 22 transcripts of audio-recordings were manually annotated by co-authors (JS, DS) using Microsoft Excel to check for the presence of any of the Omaha System problem categories (risk factors) at the utterance level. Interrater agreement between annotators was good (Fleiss’ Kappa = 0.77)31 and all discrepancies were resolved through several consensus group meetings with a senior author (MT)18. In addition, we created gold standard sets that would test for the presence of any categories at the level of the entire communication.
C. Evaluation and Comparison of NLP algorithm Performance
We applied our NLP system to the manually annotated 22 transcripts (i.e., gold standard testing set) and for each category calculated precision (i.e., positive predictive value defined as the number of true positives out of the total number of predicted positives), recall (i.e., sensitivity defined as the number of true positives out of actual number of positives), and F-score (i.e., the weighted harmonic mean of the precision and recall). Since F-measure measures both precision (the number of instances correctly classified) and robustness (not missing many instances), it is used widely to evaluate the algorithm performance. To avoid the inevitable error arising when evaluating algorithms’ performance based on the low frequency of risk factors identified during verbal communication, only risk factors found more than 20 times were used to evaluate the performance.
The performance of NLP algorithms in the auto-generated and human-generated transcripts of patient-nurse verbal communication was compared at both the utterance level and the level of the entire communication within each visit. Because of the time and effort of manually annotating both human-generated and auto-generated transcripts, we measured only precision when measuring performance on auto-generated transcripts at the utterance level. In other words, we applied the NLP algorithm on the utterances of auto-generated transcripts, then reviewed the positively labeled utterances for confirmation.
Results
Patient’s Characteristics
Among the sample of 15 patients, the average age was 67.3 (range 40.5-93.8) and 53% were male. The majority of patients were White (60%), followed by Black (33%), and Asian (7%) patients. About one-third of all patients lived alone. All patients had five or more prescription medications. The most common comorbid conditions were hypertension, chronic pulmonary disease, and diabetes (73%, 40%, and 33%, respectively). Furthermore, 33% of the visits involved postoperative care.
Verbal Communications and Transcript Accuracy
In the audio-recorded verbal communication, the average communication lasted 22 minutes (range 9 – 46.2), and each communication contained an average of 245 utterances (range 76 – 562). Out of 5,118 total utterances, 46.4% were produced by patients, and 53.6% by nurses.
The accuracy of human-generated transcripts was approximately 89% based on a random sample review of utterances from audio recordings. Many errors were caused by the transcriber’s inability to identify the specific name of the medication as part of the sentence (e.g., “The only thing here is antibiotics [inaudible]”) or by inaudible due to cross-talking or environmental noise. On the other hand, an average of the error rates across the auto-generated transcripts that were calculated against the human-generated transcripts yields a WER of 0.26 (SE: 0.004).
Identify Risk Factors for Hospitalizations or ED Visits within Patient-Nurse Verbal Communication
During the HHC visit, an average of 10 different risk factors (range 4 – 23) were manually identified. One or more risk factors were verbally discussed in approximately 7.1% (365/5118) of utterances. The problems of “Circulation,” “Pain,” and “Skin” were the most commonly mentioned at the utterance level of verbal communication. The following risk factors were mentioned over 20 times, therefore, they were included for further analysis to evaluate NLP performance: “Circulation,” “Medication regimen,” “Neuromusculoskeletal function,” “Pain,” “Respiration,” “Skin.”
Evaluation and Comparison of NLP Algorithm Performance
Table 1 provides a comparison of the risk factor identification performance on human-generated and auto-generated transcripts at the utterance level. Overall, NLP algorithms showed good risk factor identification performance at identifying risk factors for hospitalizations or ED visits within utterances on both human-generated and auto-generated transcripts, with a precision of 0.81 and 0.79, respectively. According to evaluation metrics, NLP algorithms on auto-generated transcripts performed less accurately than human-generated transcripts from the perspective of risk factor identification performance. However, a closer look at the frequency of risk factors found within utterances detected by NLP algorithms indicated large differences between the human-generated and automatic transcripts. These examples illustrated the reason auto-generated transcripts detected a significant difference in the frequency of terms compared to human-generated transcripts.
Table 1.
Example 1) The sentence within human-generated transcripts “did leg swelling [risk factor: “Circulation”] happen again?” was incorrectly transcribed in auto-generated transcripts as “is captain tommy reaction at home leah leah”. Therefore, the NLP algorithm was not able to identify the risk factor in the utterance.
Example 2) The sentence within human-generated transcripts “the problem is not really the salt but you don’t want to feel breathless [risk factor: “Respiration”]” was not captured in auto-generated transcripts. Thus, as the part of transcripts was read as “the problem is not really the salt but you dont want to yeah alright,” this utterance could not be identified as including the risk factors by the NLP algorithm.
Example 3) The sentence of human-generated transcripts “maybe they will say that insurance won’t pay” was incorrectly transcribed in auto-generated transcripts as “maybe they will say that insurance wont pain.” Thus, this was wrongly detected as having the risk factor of “pain.”
Table 2 shows a comparison of the risk prediction ability for human-generated and auto-generated transcripts on the basis of the entire verbal communication of each HHC visit. On both human-generated and auto-generated transcripts, the NLP algorithms demonstrated excellent accuracy with a low number of false positives and false negatives. F-score was 0.91 for both types of transcripts. Throughout the entire verbal communication of each HHC visit, NLP algorithms detected exactly the same risk factors, in either human-generated or auto-generated transcripts.
Table 2.
Discussion
This was the first study to investigate speech-to-text converted transcripts of patient-HHC nurse verbal communication to identify terms related to the risk for hospitalizations or ED visits during HHC. According to our recent study, verbal communication contained 50% more health problems compared to health problems captured by EHR, including structured data and narrative clinical notes18. Thus, using rich data sources, such as verbal communication, can improve recognition of problems verbally discussed during the HHC visit. This can ultimately lead to a more accurate identification of patients at risk for hospitalizations and better understanding of the risk factors during HHC. This study complements and extends our team’s recent study that developed NLP algorithms utilizing clinical notes to identify risk factors associated with HHC patient hospitalizations and ED visits32, 33.
Our findings suggested that information about risk of hospitalizations or ED visits was actively discussed verbally during HHC visits. One or more risk factors were mentioned in about 7.1% (365/5118) of utterances. The most frequently discussed risk factor was the “Circulation” problem, followed by “Pain” and “Skin”. These findings were reflected in the characteristics of patients who participated in this study; a majority of them had hypertension (73%) and 33% of the visits included postoperative care. Thus, verbal interaction between patients and nurses can provide clues as to the type of care needed. On the other hand, the remaining utterances contained (1) health-related problems that mapped to Omaha System problems categories but were not considered risk factors for hospitalizations or ED visits (e.g., sign/symptoms of ‘smokes or uses tobacco products’ under “Substance use” problem or sign/symptoms of ‘rhinorrhea or nasal congestion’ under “Respiration” problem), (2) the intervention provided (e.g., “Treatment,” “Surveillance,” “Teaching, Guidance, and Counseling” or “Case management”), (3) “small talk,” (4) answers to questions (e.g., “all right,” “yes,” etc.) and (5) clinical assessments that were within a normal range (thus they were not annotated as problems). Although these utterances constituted the majority of verbal communications, they are still important since they reinforce behaviors, confirm information, and allow for physical and emotional interaction between nurses and patients34.
Furthermore, we confirmed the potential usefulness of the NLP approaches to extract information from verbal communication for understanding risk factors in HHC. Although NLP performance was evaluated only on the six risk factors because of the nature of this pilot study that had a low frequency of risk factors annotated in transcripts, the NLP algorithm performed well for identifying risk factors found in verbal communication: human-generated transcripts have a precision of 0.81 while auto-generated transcripts have a precision of 0.79 at the utterance level; the F-score on both human-generated and auto-generated transcripts is 0.91 on entire communication. In addition, we found that NLP performance was superior when it was measured on the entire verbal communication rather than on the level of utterances. This can indicate that risk factors were mentioned many times throughout the entire verbal communication, so NLP algorithms had a higher chance of capturing them. Since this study utilized rule-based NLP approaches, it offered potential for utilizing domain knowledge directly within the information extraction process, which results in algorithms that are clinically meaningful and transparent35. However, due to the declarative nature of rule-based approaches, they are inherently inflexible to generalize to minor linguistic variations, noise, or in the case of when the input data differ only in minor nuances35. Consequently, certain risk factors, such as the “Medication regimen” problem, showed poor performance. For example, the patient explicitly stated “but I have to buy some more” in the verbal communication. Even though it implied that the medication was not in stock, it was necessary to read utterances before or after the specific utterance to understand the problem in the context. Thus, NLP algorithms were unable to identify this risk factor which was annotated by human reviewers as “fails to obtain refills appropriately” under the “Medication regimen” problem. Alternatively, machine learning-based approaches have the advantage that statistical clues from documents and clusters of related words in a document can be gleaned from the keywords, while the major challenge with machine learning is that the system has to be trained so that it can recognize and respond to queries36. To resolve some of these issues, the use of hybrid NLP approaches that combine the rule-based and machine learning-based NLP approaches should be considered in future studies.
This study also aimed to compare human-generated transcripts and automatic transcripts in terms of NLP performance. This aim set out to explore, in the sense of a proof-of-concept, whether auto-generated transcripts could potentially replace the need for human-generated transcripts for the purpose of identifying risk factors for hospitalizations or ED visits in HHC through the application of NLP algorithms. In terms of prediction ability at the utterance level, NLP algorithms on auto-generated transcripts performed slightly worse than human-generated transcripts. Nevertheless, the fundamental issue was that some key terms or expressions were not captured due to the inaccuracy of the auto-generated transcripts, therefore, comparing the risk factor identification performance of two types of transcripts solely on the basis of evaluation metrics needs to be reconsidered. The automatic speech recognition (i.e., Amazon Transcribe Medical service for this study) uses statistical probabilities to deduce whole words from phonemes, and then derives complete sentences from these full words by analyzing them sequentially, starting from the first phoneme16. For this reason, the presence of grammatical errors, disfluencies, and other imperfections in recorded verbal communication can generate errors in auto-generated transcripts, then errors introduced by either the speaker or the automatic speech recognition system will be propagated to the next task, such as the development of NLP algorithms. Thus, we suggest sophisticated post-processing from an automatic speech recognition output should be applied in order to turn unintelligible text into readable text while maintaining the semantic meaning of the speaker37.
The previous studies which used the auto-generated transcript for voice recordings (i.e., qualitative interview, physician note dictating, or reporting pathology results) were mostly recorded in a quiet environment or the voice recording devices were directly connected to a desktop computer38-40. Therefore, the quality of transcripts in such controlled environments might be higher. For this study, despite using the noise removal feature to create the auto-transcript, due to the nature of HHC services offered in the home environment, the quality of our voice recordings between patients and nurses could be inferior to those recorded in a more controlled environment. Indeed, some of the recordings used in this study had constant background sounds (such as television noise, cross-talking, or distant caregiver voices), or the recorded voice was too far away while nurses provided certain interventions. Hence, there is a need to identify how to integrate speech-recognition into HHC clinical workflows and collect high-quality recordings, which will likely improve transcript accuracy.
Clinical implications and future research
Our findings showed that NLP algorithms risk factor identification performance was relatively high. Future studies need to expand the sample size to determine whether the algorithm is effective with all the risk factors for hospitalizations or ED visits in HHC. In addition, given the diversity of the population in HHC organizations, further research is needed on how these NLP algorithms work for patients or nurses whom English is not the primary language. Future NLP algorithms should be able to be flexible in their use to deal with grammatical errors or unusual expressions from non-native speakers.
Further efforts are also needed to improve the accuracy of the auto-generated transcripts. Nonetheless, this study’s results suggest that automated voice recognition technologies could potentially be used to capture patient-nurse verbal communication and create clinical records in the EHR to (1) reduce the time and costs associated with human-generated documentation, and (2) reduce clinician burnout and cognitive load as a result of a heavy documentation load41, 42. With these insights, predictive analytics may also improve the identification of patients at risk for negative outcomes (e.g., hospitalizations or ED visits).
Limitations
Since this pilot study was exploratory, it has a small sample size, which can affect the generalizability of the results. However, at the utterance level, we analyzed over 5,000 utterances that were empirically acceptable for the classification task. In addition, the analysis of audio recordings of patient-nurse verbal communication was only performed at one HHC organization in the same geographical area, thus limiting generalizability due to the possibility of organizational-specific practice patterns (for instance, certain care protocols during HHC visits). The participants were not limited to native speakers. Since participants whose first language is not English may influence the quality of content of audio recordings. Although the NLP algorithm has been refined to include verbal communication, a small percentage of utterances may not provide sufficient data to detect statistical associations in a text containing verbal communication. Lastly, as verbal communication was directly reflected an individual’s knowledge, perception, and attitude, the communication could be influenced by a range of factors, including the nurse’s individual communication style.
Conclusion
This study highlights the potential application of NLP approaches for detecting care needs in HHC by extracting information from verbal communication. The NLP algorithm performed well for identifying risk factors in verbal communication, with precision of over 0.79 at an utterance level and F-score of 0.91 on the entire communication. The risk factor identification performance of the NLP algorithm on auto-generated transcripts performed slightly worse at the utterance level than those on human-generated transcripts, but it was equally good over the entire communication. However, it is not yet possible to determine the usability of auto-generated patient-nurse communication just based on these pilot results. Future research should prioritize improving the accuracy of auto-generated transcripts to determine whether they can potentially replace human-generated transcripts for identifying risk factors for hospitalizations or ED visits in HHC by applying NLP algorithms.
Acknowledgements
This study is funded by the pilot grant from Columbia University School of Nursing (Clinical Meaningful Concept in Communication “MC-ICON”) and the Pilot Grant from Columbia University Center of Artificial Intelligence Technology (“Using artificial intelligence to identify homecare patient’s risk of hospitalization and emergency department visits: speech-recognition feasibility study”).
Figures & Table
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