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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1993 May;56(5):526–530. doi: 10.1136/jnnp.56.5.526

The use of botulinum toxin in the treatment of adductor spasmodic dysphonia.

R Whurr 1, M Lorch 1, H Fontana 1, G Brookes 1, A Lees 1, C D Marsden 1
PMCID: PMC1015013  PMID: 8505645

Abstract

Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of the speech sample, indicating a reduction in the variability of pitch amongst patients. A total of 96% of patients' subjective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.

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Selected References

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