Abstract
To clarify the contribution of cerebral amyloid angiopathy (CAA) to subarachnoid haemorrhage (SAH) in the elderly, relationships between SAH and CAA were investigated in 997 necropsy cases aged 60 years or older. Primary SAH (bleeding from subarachnoid vessels) was found in 15 cases (1.5%). There was no case in which primary SAH was clearly attributed to CAA. Secondary SAH [secondary rupture of intracerebral haemorrhage (ICH) through the cortex to the subarachnoid space] was found in 23 patients (2.3%). In 11 (48%) of them, ICH with secondary SAH was associated with CAA. The results indicated that primary SAH is rarely related to CAA, however, CAA is the most frequent cause of ICH accompanying secondary SAH in the elderly.
Full text
PDF




Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cosgrove G. R., Leblanc R., Meagher-Villemure K., Ethier R. Cerebral amyloid angiopathy. Neurology. 1985 May;35(5):625–631. doi: 10.1212/wnl.35.5.625. [DOI] [PubMed] [Google Scholar]
- Esiri M. M., Wilcock G. K. Cerebral amyloid angiopathy in dementia and old age. J Neurol Neurosurg Psychiatry. 1986 Nov;49(11):1221–1226. doi: 10.1136/jnnp.49.11.1221. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Finelli P. F., Kessimian N., Bernstein P. W. Cerebral amyloid angiopathy manifesting as recurrent intracerebral hemorrhage. Arch Neurol. 1984 Mar;41(3):330–333. doi: 10.1001/archneur.1984.04050150112027. [DOI] [PubMed] [Google Scholar]
- Gilbert J. J., Vinters H. V. Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage. Stroke. 1983 Nov-Dec;14(6):915–923. doi: 10.1161/01.str.14.6.915. [DOI] [PubMed] [Google Scholar]
- Gray F., Dubas F., Roullet E., Escourolle R. Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol. 1985 Jul;18(1):54–59. doi: 10.1002/ana.410180110. [DOI] [PubMed] [Google Scholar]
- Ishii N., Nishihara Y., Horie A. Amyloid angiopathy and lobar cerebral haemorrhage. J Neurol Neurosurg Psychiatry. 1984 Nov;47(11):1203–1210. doi: 10.1136/jnnp.47.11.1203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jellinger K. Cerebrovascular amyloidosis with cerebral hemorrhage. J Neurol. 1977 Feb 17;214(3):195–206. doi: 10.1007/BF00316150. [DOI] [PubMed] [Google Scholar]
- Kalyan-Raman U. P., Kalyan-Raman K. Cerebral amyloid angiopathy causing intracranial hemorrhage. Ann Neurol. 1984 Sep;16(3):321–329. doi: 10.1002/ana.410160308. [DOI] [PubMed] [Google Scholar]
- Mandybur T. I., Bates S. R. Fatal massive intracerebral hemorrhage complicating cerebral amyloid angiopathy. Arch Neurol. 1978 Apr;35(4):246–248. doi: 10.1001/archneur.1978.00500280064014. [DOI] [PubMed] [Google Scholar]
- Mandybur T. I. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol. 1986 Jan;45(1):79–90. [PubMed] [Google Scholar]
- Mandybur T. I. The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology. 1975 Feb;25(2):120–126. doi: 10.1212/wnl.25.2.120. [DOI] [PubMed] [Google Scholar]
- Masuda J., Tanaka K., Ueda K., Omae T. Autopsy study of incidence and distribution of cerebral amyloid angiopathy in Hisayama, Japan. Stroke. 1988 Feb;19(2):205–210. doi: 10.1161/01.str.19.2.205. [DOI] [PubMed] [Google Scholar]
- Morimatsu M., Hirai S., Muramatsu A., Yoshikawa M. Senile degenerative brain lesions and dementia. J Am Geriatr Soc. 1975 Sep;23(9):390–406. doi: 10.1111/j.1532-5415.1975.tb00425.x. [DOI] [PubMed] [Google Scholar]
- Okazaki H., Reagan T. J., Campbell R. J. Clinicopathologic studies of primary cerebral amyloid angiopathy. Mayo Clin Proc. 1979 Jan;54(1):22–31. [PubMed] [Google Scholar]
- Tomonaga M. Cerebral amyloid angiopathy in the elderly. J Am Geriatr Soc. 1981 Apr;29(4):151–157. doi: 10.1111/j.1532-5415.1981.tb01757.x. [DOI] [PubMed] [Google Scholar]
- Torack R. M. Congophilic angiopathy complicated by surgery and massive hemorrhage. A light and electron microscopic study. Am J Pathol. 1975 Nov;81(2):349–366. [PMC free article] [PubMed] [Google Scholar]
- Tyler K. L., Poletti C. E., Heros R. C. Cerebral amyloid angiopathy with multiple intracerebral hemorrhages. Case report. J Neurosurg. 1982 Aug;57(2):286–289. doi: 10.3171/jns.1982.57.2.0286. [DOI] [PubMed] [Google Scholar]
- Vinters H. V. Cerebral amyloid angiopathy. A critical review. Stroke. 1987 Mar-Apr;18(2):311–324. doi: 10.1161/01.str.18.2.311. [DOI] [PubMed] [Google Scholar]
- Vinters H. V., Gilbert J. J. Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke. 1983 Nov-Dec;14(6):924–928. doi: 10.1161/01.str.14.6.924. [DOI] [PubMed] [Google Scholar]
- Vonsattel J. P., Myers R. H., Hedley-Whyte E. T., Ropper A. H., Bird E. D., Richardson E. P., Jr Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study. Ann Neurol. 1991 Nov;30(5):637–649. doi: 10.1002/ana.410300503. [DOI] [PubMed] [Google Scholar]
- Yamada M., Tsukagoshi H., Otomo E., Hayakawa M. Cerebral amyloid angiopathy in the aged. J Neurol. 1987 Aug;234(6):371–376. doi: 10.1007/BF00314080. [DOI] [PubMed] [Google Scholar]
- Yamada M., Tsukagoshi H., Otomo E., Hayakawa M. Systemic amyloid deposition in old age and dementia of Alzheimer type: the relationship of brain amyloid to other amyloid. Acta Neuropathol. 1988;77(2):136–141. doi: 10.1007/BF00687423. [DOI] [PubMed] [Google Scholar]



