Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2023 Apr 17:2023.04.17.537163. [Version 1] doi: 10.1101/2023.04.17.537163

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

PMC Copyright notice

Figure 1: — Overview of approach and hypothesized mechanism. (A) Genetic constructs used. (B) Suggested mechanism of action for FGF2/Ras^G12V, where FGF2 is secreted¹⁷, complexes with FGFR1, and activates pathways to promote proliferation and inhibit fusion. At the same time, Ras^G12V constitutively activates the Ras/Raf/Mek/ERK pathway, and potentially further activates the expressed FGF2¹⁶.