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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1992 Dec;55(12):1205–1206. doi: 10.1136/jnnp.55.12.1205

Prolactin secreting pituitary carcinoma.

T Petterson 1, I A MacFarlane 1, J M MacKenzie 1, M D Shaw 1
PMCID: PMC1015342  PMID: 1479402

Abstract

A man with a prolactin secreting pituitary carcinoma was treated by surgery and radiotherapy. Persistent hyperprolactinaemia partially responded to oral bromocriptine for four years. Serum prolactin then rose considerably with rapid, invasive tumour recurrence. Cytotoxic chemotherapy halted tumour progression for twelve months before fatal spread throughout the brain. Failure to normalise serum prolactin with bromocriptine may precede an aggressive course in patients with prolactinoma.

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Selected References

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