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. 1993 Dec;56(12):1317–1320. doi: 10.1136/jnnp.56.12.1317

Seizures due to multiple sclerosis: seven patients with MRI correlations.

A J Thompson 1, A G Kermode 1, I F Moseley 1, D G MacManus 1, W I McDonald 1
PMCID: PMC1015382  PMID: 8270935

Abstract

The MRI data of seven patients with clinically definite multiple sclerosis who developed epileptic seizures are presented. Six of these cases demonstrated new or enhancing lesions. Cerebral biopsy in one of these lesions confirmed inflammation with myelin breakdown products. Lesions implicated in the causation of seizures involved the cortex or subcortical area. In one patient, a new lesion was associated with EEG abnormalities which resolved as the lesion reduced in size. In three patients epileptic activity was the only clinical manifestation of disease. Large, unresolving lesions tended to be associated with continuing seizures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWNELL B., HUGHES J. T. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1962 Nov;25:315–320. doi: 10.1136/jnnp.25.4.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DRAKE W. E., Jr, MACRAE D. Epilepsy in multiple sclerosis. Neurology. 1961 Sep;11:810–816. doi: 10.1212/wnl.11.9.810. [DOI] [PubMed] [Google Scholar]
  3. Ekbom K. A., Westerberg C. E., Osterman P. O. Focal sensory-motor seizures of spinal origin. Lancet. 1968 Jan 13;1(7533):67–67. doi: 10.1016/s0140-6736(68)90067-6. [DOI] [PubMed] [Google Scholar]
  4. Ghezzi A., Montanini R., Basso P. F., Zaffaroni M., Massimo E., Cazzullo C. L. Epilepsy in multiple sclerosis. Eur Neurol. 1990;30(4):218–223. doi: 10.1159/000117350. [DOI] [PubMed] [Google Scholar]
  5. Kermode A. G., Thompson A. J., Tofts P., MacManus D. G., Kendall B. E., Kingsley D. P., Moseley I. F., Rudge P., McDonald W. I. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications. Brain. 1990 Oct;113(Pt 5):1477–1489. doi: 10.1093/brain/113.5.1477. [DOI] [PubMed] [Google Scholar]
  6. Kermode A. G., Tofts P. S., Thompson A. J., MacManus D. G., Rudge P., Kendall B. E., Kingsley D. P., Moseley I. F., du Boulay E. P., McDonald W. I. Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement. Neurology. 1990 Feb;40(2):229–235. doi: 10.1212/wnl.40.2.229. [DOI] [PubMed] [Google Scholar]
  7. Kieburtz K., Ricotta J. J., Moxley R. T., 3rd Seizures following carotid endarterectomy. Arch Neurol. 1990 May;47(5):568–570. doi: 10.1001/archneur.1990.00530050092017. [DOI] [PubMed] [Google Scholar]
  8. Kinnunen E., Wikström J. Prevalence and prognosis of epilepsy in patients with multiple sclerosis. Epilepsia. 1986 Nov-Dec;27(6):729–733. doi: 10.1111/j.1528-1157.1986.tb03602.x. [DOI] [PubMed] [Google Scholar]
  9. Kurtzke J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–1452. doi: 10.1212/wnl.33.11.1444. [DOI] [PubMed] [Google Scholar]
  10. MATTHEWS W. B. Epilepsy and disseminated sclerosis. Q J Med. 1962 Apr;31:141–155. [PubMed] [Google Scholar]
  11. Ormerod I. E., Miller D. H., McDonald W. I., du Boulay E. P., Rudge P., Kendall B. E., Moseley I. F., Johnson G., Tofts P. S., Halliday A. M. The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions. A quantitative study. Brain. 1987 Dec;110(Pt 6):1579–1616. doi: 10.1093/brain/110.6.1579. [DOI] [PubMed] [Google Scholar]
  12. Ostermann P. O., Westerberg C. E. Paroxysmal attacks in multiple sclerosis. Brain. 1975 Jun;98(2):189–202. doi: 10.1093/brain/98.2.189. [DOI] [PubMed] [Google Scholar]
  13. Plant G. T., Kermode A. G., Turano G., Moseley I. F., Miller D. H., MacManus D. G., Halliday A. M., McDonald W. I. Symptomatic retrochiasmal lesions in multiple sclerosis: clinical features, visual evoked potentials, and magnetic resonance imaging. Neurology. 1992 Jan;42(1):68–76. doi: 10.1212/wnl.42.1.68. [DOI] [PubMed] [Google Scholar]
  14. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  15. RICHARDSON E. P., Jr, DODGE P. R. Epilepsy in cerebral vascular disease; a study of the incidence and nature of seizures in 104 consecutive autopsy-proven cases of cerebral infarction and hemorrhage. Epilepsia. 1954 Nov;3:49–74. doi: 10.1111/j.1528-1157.1954.tb03153.x. [DOI] [PubMed] [Google Scholar]
  16. Roberts R. C., Shorvon S. D., Cox T. C., Gilliatt R. W. Clinically unsuspected cerebral infarction revealed by computed tomography scanning in late onset epilepsy. Epilepsia. 1988 Mar-Apr;29(2):190–194. doi: 10.1111/j.1528-1157.1988.tb04418.x. [DOI] [PubMed] [Google Scholar]
  17. Sagar H. J., Warlow C. P., Sheldon P. W., Esiri M. M. Multiple sclerosis with clinical and radiological features of cerebral tumour. J Neurol Neurosurg Psychiatry. 1982 Sep;45(9):802–808. doi: 10.1136/jnnp.45.9.802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Shibasaki H., McDonald W. I., Kuroiwa Y. Racial modification of clinical picture of multiple sclerosis: comparison between British and Japanese patients. J Neurol Sci. 1981 Feb;49(2):253–271. doi: 10.1016/0022-510x(81)90083-6. [DOI] [PubMed] [Google Scholar]
  19. Thompson A. J., Kermode A. G., Wicks D., MacManus D. G., Kendall B. E., Kingsley D. P., McDonald W. I. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol. 1991 Jan;29(1):53–62. doi: 10.1002/ana.410290111. [DOI] [PubMed] [Google Scholar]
  20. Youl B. D., Kermode A. G., Thompson A. J., Révész T., Scaravilli F., Barnard R. O., Kirkham F. J., Kendall B. E., Kingsley D., Moseley I. F. Destructive lesions in demyelinating disease. J Neurol Neurosurg Psychiatry. 1991 Apr;54(4):288–292. doi: 10.1136/jnnp.54.4.288. [DOI] [PMC free article] [PubMed] [Google Scholar]

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