Skip to main content
NCBI home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1988 Jan;25(1):29–31. doi: 10.1136/jmg.25.1.29

Polymorphic acetylation of sulphamethazine in a Zimbabwe population.

C F Nhachi 1
PMCID: PMC1015418  PMID: 3351888

Abstract

Sulphamethazine, 8 mg/kg body weight, was administered orally in tablet form to 100 healthy volunteers and total and free sulphamethazine were determined in the six hour urine sample. The bimodal population frequency distribution for percentage acetylated sulphamethazine showed 42 of the tested population to be fast and 58 to be slow acetylators, that is, an estimation of q = 0.72 +/- 0.3 as the frequency of the allele controlling slow acetylation. The study also revealed ample evidence that the assay of the drug in urine can be done in a significantly shorter time.

Full text

PDF
29

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DEVADATTA S., GANGADHARAM P. R., ANDREWS R. H., FOX W., RAMAKRISHNAN C. V., SELKON J. B., VELU S. Peripheral neuritis due to isoniazid. Bull World Health Organ. 1960;23:587–598. [PMC free article] [PubMed] [Google Scholar]
  2. EVANS D. A., WHITE T. A. HUMAN ACETYLATION POLYMORPHISM. J Lab Clin Med. 1964 Mar;63:394–403. [PubMed] [Google Scholar]
  3. Ellard G. A., Gammon P. T., Titinen H. Determination of the acetylator phenotype using matrix isoniazid. Tubercle. 1975 Sep;56(3):203–209. doi: 10.1016/0041-3879(75)90053-7. [DOI] [PubMed] [Google Scholar]
  4. Ellard G. A. Variations between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis. Clin Pharmacol Ther. 1976 May;19(5 Pt 2):610–625. doi: 10.1002/cpt1976195part2610. [DOI] [PubMed] [Google Scholar]
  5. Evans D. A. An improved and simplified method of detecting the acetylator phenotype. J Med Genet. 1969 Dec;6(4):405–407. doi: 10.1136/jmg.6.4.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Eze L. C., Obidoa O. Acetylation of sulfamethazine in a Nigerian population. Biochem Genet. 1978 Dec;16(11-12):1073–1077. doi: 10.1007/BF00484527. [DOI] [PubMed] [Google Scholar]
  7. Fawcett I. W., Gammon P. T. Determination of the acetylator phenotype in a Northern Nigerian population. Tubercle. 1975 Sep;56(3):199–201. doi: 10.1016/0041-3879(75)90052-5. [DOI] [PubMed] [Google Scholar]
  8. Growth after malnutrition. Br Med J. 1970 May 30;2(5708):495–496. [PMC free article] [PubMed] [Google Scholar]
  9. Jeyakumar L. H., French M. R. Polymorphic acetylation of sulfamethazine in a Nigerian (Yoruba) population. Xenobiotica. 1981 May;11(5):319–321. doi: 10.3109/00498258109045310. [DOI] [PubMed] [Google Scholar]
  10. Peters J. H. Genetic factors in relation to drugs. Annu Rev Pharmacol. 1968;8:427–452. doi: 10.1146/annurev.pa.08.040168.002235. [DOI] [PubMed] [Google Scholar]
  11. Peters J. H., Miller K. S., Brown P. Studies on the metabolic basis for the genetically determined capacities for isoniazid inactivation in man. J Pharmacol Exp Ther. 1965 Nov;150(2):298–304. [PubMed] [Google Scholar]
  12. SUNAHARA S., URANOM, OGAWAM Genetical and geographic studies on isoniazid inactivation. Science. 1961 Nov 10;134(3489):1530–1531. doi: 10.1126/science.134.3489.1530. [DOI] [PubMed] [Google Scholar]
  13. White T. A., Evans D. A. The actylation of sulamethazine and sulfamethoxypyridazine by human subjects. Clin Pharmacol Ther. 1968 Jan-Feb;9(1):80–88. doi: 10.1002/cpt19689180. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES