Abstract
We review the published reports on reproduction in cases of non-mosaic trisomy 21 (Down's syndrome) and present the first fully documented case of a non-mosaic male with Down's syndrome fathering a pregnancy, a fact which has important implications in the light of caring for these people in the community.
Full text
PDF




Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALLEN G., BAROFF G. S. Mongoloid twins and their siblings. Acta Genet Stat Med. 1955;5(4):294–326. doi: 10.1159/000150779. [DOI] [PubMed] [Google Scholar]
- Daikoku N. H., Kaltreider D. F., Khouzami V. A., Spence M., Johnson J. W. Premature rupture of membranes and spontaneous preterm labor: maternal endometritis risks. Obstet Gynecol. 1982 Jan;59(1):13–20. [PubMed] [Google Scholar]
- FORSSMAN H., LEHMANN O., THYSELL T. Reproduction in mongolism. Chromosome studies and re-examination of a child. Am J Ment Defic. 1961 Jan;65:495–498. [PubMed] [Google Scholar]
- FORSSMAN H., THYSELL T. A woman with mongolism and her child. Am J Ment Defic. 1957 Nov;62(3):500–503. [PubMed] [Google Scholar]
- Finley W. H., Finley S. C., Hardy J. P., McKinnon T. Down's syndrome in mother and child. Obstet Gynecol. 1968 Aug;32(2):200–201. [PubMed] [Google Scholar]
- Francesconi D., Guaschino S. Trisomy 21 in mother and daughter. Clin Genet. 1976 Mar;9(3):346–346. doi: 10.1111/j.1399-0004.1976.tb01584.x. [DOI] [PubMed] [Google Scholar]
- Friedman J. M., Sternberg W. H., Varela M., Barclay D. L. Trisomy-21 in mother and child. Report of a case. Obstet Gynecol. 1970 Nov;36(5):731–734. [PubMed] [Google Scholar]
- Fuchs-Mecke S., Passarge E. Kinder von Müttern mit Down-Syndrom (Mongolismus. Dtsch Med Wochenschr. 1972 Mar 3;97(9):338–341. doi: 10.1055/s-0028-1107352. [DOI] [PubMed] [Google Scholar]
- GOODALE F., LEE K. T., THOMAS W. A. Sex-distribution of myocardial infarction. Lancet. 1961 May 20;1(7186):1115–1115. doi: 10.1016/s0140-6736(61)92346-7. [DOI] [PubMed] [Google Scholar]
- Grall J. Y., Le Goux A. M., Le Marec B., Picard F., Larget-Piet L., Dubois J. Fécondité des sujets trisomiques 21. Une observation. 1978 Aug 26-Sep 2Nouv Presse Med. 7(28):2459–2460. [PubMed] [Google Scholar]
- HANHART E. [Mongoloid idiocy in mother and two children from an incestuous relationship]. Acta Genet Med Gemellol (Roma) 1960 Jan;9:112–130. [PubMed] [Google Scholar]
- Hook E. B. Exclusion of chromosomal mosaicism: tables of 90%, 95% and 99% confidence limits and comments on use. Am J Hum Genet. 1977 Jan;29(1):94–97. [PMC free article] [PubMed] [Google Scholar]
- Højager B., Peters H., Byskov A. G., Faber M. Follicular development in ovaries of children with Down's syndrome. Acta Paediatr Scand. 1978 Sep;67(5):637–643. doi: 10.1111/j.1651-2227.1978.tb17815.x. [DOI] [PubMed] [Google Scholar]
- JOHNSTON A. W., JASLOW R. I. Children of mothers with Down's syndrome. N Engl J Med. 1963 Aug 29;269:439–443. doi: 10.1056/NEJM196308292690902. [DOI] [PubMed] [Google Scholar]
- Jeffreys A. J., Wilson V., Thein S. L. Hypervariable 'minisatellite' regions in human DNA. Nature. 1985 Mar 7;314(6006):67–73. doi: 10.1038/314067a0. [DOI] [PubMed] [Google Scholar]
- Jeffreys A. J., Wilson V., Thein S. L., Weatherall D. J., Ponder B. A. DNA "fingerprints" and segregation analysis of multiple markers in human pedigrees. Am J Hum Genet. 1986 Jul;39(1):11–24. [PMC free article] [PubMed] [Google Scholar]
- Johannisson R., Gropp A., Winking H., Coerdt W., Rehder H., Schwinger E. Down's syndrome in the male. Reproductive pathology and meiotic studies. Hum Genet. 1983;63(2):132–138. doi: 10.1007/BF00291532. [DOI] [PubMed] [Google Scholar]
- Le Marec B., Picard F., Larget-Piet L., Le Goux A. M., Grall J. Y., Sénécal J. Amniocentèse chez une trisomique 21 avec foetus à caryotype normal mais porteur de malformations. Arch Fr Pediatr. 1978 May;35(5):546–550. [PubMed] [Google Scholar]
- MULLINS D. H., ESTRADA W. R., GREADY T. G. Pregnancy in an adult mongoloid female: report of a case. Obstet Gynecol. 1960 Jun;15:781–783. [PubMed] [Google Scholar]
- Masterson J. G., Law E. M., Power M. M., Stokes B. M., Murphy D. Reproduction in two females with Down's syndrome. Ann Genet. 1970 Mar;13(1):38–41. [PubMed] [Google Scholar]
- Moric-Petrovic S., Garzicic B. Mother with Down's syndrome and her child. J Ment Defic Res. 1970 Mar;14(1):68–76. doi: 10.1111/j.1365-2788.1970.tb01100.x. [DOI] [PubMed] [Google Scholar]
- PRIEST J. H., THULINE H. C., NORBY D. E., LAVECK G. D. Reproduction in human autosomal trisomics. Chromosome studies of a mongol mother, her nonmongol twins, and her family. Am J Dis Child. 1963 Jan;105:31–41. [PubMed] [Google Scholar]
- REHN A. T., THOMAS E., Jr Family history of a mongoloid girl who bore a mongoloid child. Am J Ment Defic. 1957 Nov;62(3):496–499. [PubMed] [Google Scholar]
- Reiss J. A., Lovrien E. W., Hecht F. A mother with Down's syndrome and her chromosomally normal infant. Ann Genet. 1971 Sep;14(3):225–227. [PubMed] [Google Scholar]
- Rethoré M. O., Lafourcade J., Prieur M., Caille B., Cruveillier C. J., Tanzy M., Lejeune J. Mère et fille trisomiques 21 libres. Ann Genet. 1970 Mar;13(1):42–45. [PubMed] [Google Scholar]
- Rodeck C. H., Morsman J. M., Nicolaides K. H., McKenzie C., Gosden C. M., Gosden J. R. A single-operator technique for first-trimester chorion biopsy. Lancet. 1983 Dec 10;2(8363):1340–1341. doi: 10.1016/s0140-6736(83)91095-4. [DOI] [PubMed] [Google Scholar]
- SAWYER G. M., SHAFTER A. J. Reproduction in a mongoloid: a follow-up. Am J Ment Defic. 1957 Apr;61(4):793–795. [PubMed] [Google Scholar]
- SCHLAUG R. A mongolian mother and her child; a case report. Acta Genet Stat Med. 1957;7(3):533–540. [PubMed] [Google Scholar]
- STEARNS P. E., DROULARD K. E., SAHHAR F. H. Studies bearing on fertility of male and female mongoloids. Am J Ment Defic. 1960 Jul;65:37–41. [PubMed] [Google Scholar]
- STILES K. A., GOODMAN H. O. Reproduction in a mongoloid. Acta Genet Med Gemellol (Roma) 1961 Oct;10:457–469. doi: 10.1017/s1120962300016784. [DOI] [PubMed] [Google Scholar]
- Scharrer S., Stengel-Rutkowski S., Rodewald-Rudescu A., Erdlen E., Zang K. D. Reproduction in a female patient with Down's syndrome. Case report of a 46, XY child showing slight phenotypical anomalies, born to a 47, XX, + 21 mother. Humangenetik. 1975;26(3):207–214. [PubMed] [Google Scholar]
- THOMPSON M. W. 21-trisomy in a fertile female mongol. Can J Genet Cytol. 1962 Sep;4:352–355. doi: 10.1139/g62-045. [DOI] [PubMed] [Google Scholar]
- THOMPSON M. W. Reproduction in two female mongols. Can J Genet Cytol. 1961 Dec;3:351–354. doi: 10.1139/g61-041. [DOI] [PubMed] [Google Scholar]
- Tagher P., Reisman L. E. Reproduction in down's syndrome (mongolism): chromosomal study of mother and normal child. Obstet Gynecol. 1966 Feb;27(2):182–184. [PubMed] [Google Scholar]
- Van De Velde-Staquet M. F., Breynaert R., Walbaum R., Saint-Aubert P., Farriaux J. P., Fontaine G. La descendance des méres trisomiques 21 (a propos d'une observation) J Genet Hum. 1973 Sep;21(3):187–206. [PubMed] [Google Scholar]

