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Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1989 Jun;26(6):379–381. doi: 10.1136/jmg.26.6.379

Chromosome studies of males in an institution for the mentally handicapped.

C J English 1, E V Davison 1, M S Bhate 1, L Barrett 1
PMCID: PMC1015622  PMID: 2525623

Abstract

Karyotypes were examined in 512 (91.9%) of 557 male patients in an institution for the mentally handicapped. A total of 110 (21.5%) had an abnormal karyotype: 65 (12.7%) with Down's syndrome, 30 (5.9%) with the fragile X syndrome, 13 (2.5%) with autosomal anomalies other than Down's syndrome (12 unbalanced, one balanced), and two (0.4%) with sex chromosome anomalies.

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Selected References

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  1. Blomquist H. K., Gustavson K. H., Holmgren G., Nordenson I., Pålsson-Stråe U. Fragile X syndrome in mildly mentally retarded children in a northern Swedish county. A prevalence study. Clin Genet. 1983 Dec;24(6):393–398. doi: 10.1111/j.1399-0004.1983.tb00092.x. [DOI] [PubMed] [Google Scholar]
  2. Breg W. R., Miller D. A., Allderdice P. W., Miller O. J. Identification of translocation chromosomes by quinacrine fluorescence. Am J Dis Child. 1972 Jun;123(6):561–564. doi: 10.1001/archpedi.1972.02110120085007. [DOI] [PubMed] [Google Scholar]
  3. Brown W. M. Sex chromosome aneuploidy in man and its frequency, with special reference to mental subnormality and criminal behavior. Int Rev Exp Pathol. 1969;7:31–97. [PubMed] [Google Scholar]
  4. Cassiman J. J., Fryns J. P., De Roover J., Van den Berghe H. Sex chromatin and cytogenetic survey of 10417 adult males and 357 children institutionalized in Belgian institutions for mentally retarded patients. Humangenetik. 1975 May 26;28(1):43–48. doi: 10.1007/BF00272481. [DOI] [PubMed] [Google Scholar]
  5. Giraud F., Mattei J. F. Aspects epidémiologiques de la trisomie 21. J Genet Hum. 1975 Oct;23(Suppl):1–30. [PubMed] [Google Scholar]
  6. Gustavson K. H., Blomquist H. K., Holmgren G. Prevalence of the fragile-X syndrome in mentally retarded boys in a Swedish county. Am J Med Genet. 1986 Jan-Feb;23(1-2):581–587. doi: 10.1002/ajmg.1320230152. [DOI] [PubMed] [Google Scholar]
  7. Jacobs P. A. Correlation between euploid structural chromosome rearrangements and mental subnormality in humans. Nature. 1974 May 10;249(453):164–165. doi: 10.1038/249164a0. [DOI] [PubMed] [Google Scholar]
  8. Jacobs P. A., Matsuura J. S., Mayer M., Newlands I. M. A cytogenetic survey of an institution for the mentally retarded: I. Chromosome abnormalities. Clin Genet. 1978 Jan;13(1):37–60. doi: 10.1111/j.1399-0004.1978.tb04127.x. [DOI] [PubMed] [Google Scholar]
  9. Kinnell H. G., Banu S. P. Institutional prevalence of fragile X syndrome. Lancet. 1983 Dec 17;2(8364):1427–1427. doi: 10.1016/s0140-6736(83)90963-7. [DOI] [PubMed] [Google Scholar]
  10. Newton M. S., Cunningham C., Jacobs P. A., Price W. H., Fraser I. A. Chromosome survey of a hospital for the mentally subnormal. 2. Autosome abnormalities. Clin Genet. 1972;3(4):226–248. doi: 10.1111/j.1399-0004.1972.tb04271.x. [DOI] [PubMed] [Google Scholar]
  11. Newton M. S., Jacobs P. A., Price W. H., Woodcock G., Fraser I. A. A chromosome survey of a hospital for the mentally subnormal. 1. Sex chromosome abnormalities. Clin Genet. 1972;3(4):215–225. doi: 10.1111/j.1399-0004.1972.tb04270.x. [DOI] [PubMed] [Google Scholar]
  12. Primrose D. A., el-Matmati R., Boyd E., Gosden C., Newton M. Prevalence of the fragile X syndrome in an institution for the mentally handicapped. Br J Psychiatry. 1986 Jun;148:655–657. doi: 10.1192/bjp.148.6.655. [DOI] [PubMed] [Google Scholar]
  13. Speed R. M., Johnston A. W., Evans H. J. Chromosome survey of total population of mentally subnormal in North-East of Scotland. J Med Genet. 1976 Aug;13(4):295–306. doi: 10.1136/jmg.13.4.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sutherland G. R., Murch A. R., Gardiner A. J., Carter R. F., Wiseman C. Cytogenetic survey of a hospital for the mentally retarded. Hum Genet. 1976 Dec 15;34(3):231–245. doi: 10.1007/BF00295286. [DOI] [PubMed] [Google Scholar]

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