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. 1989 Jul;26(7):426–430. doi: 10.1136/jmg.26.7.426

Testing for cystic fibrosis using allelic association.

A J Ivinson 1, A P Read 1, R Harris 1, M Super 1, M Schwarz 1, J Clayton Smith 1, R Elles 1
PMCID: PMC1015644  PMID: 2746614

Abstract

A particular haplotype defined by probes XV2c, KM19, and CS.7 at the D7S23 locus was found on 90% of chromosomes which carry cystic fibrosis (CF), but on only 11% of normal chromosomes in a UK sample of CF carriers. We show how such data can be used to calculate carrier risks for people with and without a family history of CF, and give examples of clinical applications. For parents or sibs of dead CF patients, phase and genotypes can often be assigned with only 1 to 2% error. However, this method is not suitable for prenatal testing where there is no history of CF; for couples with no family history, no fetus can be shown to be at more than 2% risk of being affected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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