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. 2023 Apr 9;13(7):2226–2240. doi: 10.7150/thno.81325

Figure 2.

Figure 2

PTT using PFI evokes severe pain. (A) SEM image of PFI. Scale bar is 10 μm. (B) PFI at 4 ℃ and 37 ℃. (C) Temperature-dependent rheology of PFI aqueous dispersion. (D) Frequency-dependent rheology of PFI hydrogel at 37 °C. (E) The shear-thinning behavior of PFI hydrogel indicated by steady-shear rheology. (F) Statistical results of the degree of tumor temperature change (ΔT) (n=3). (G) IR thermal image of mice under 808 nm laser irradiation at different power densities. (H) Schematic of mechanical withdrawal threshold measurement. The force of the mouse to withdraw mechanical stimulation was recorded using the electronic Von Frey. (I) Mechanical withdrawal threshold was measured at 0, 4, 12, and 24 h after irradiation under different laser power densities (n=5). (J) Immunofluorescent staining of TRPV1 and CGRP in the dorsal root ganglion (DRG). DRGs were obtained at 6 h after PTT (1.2 W/cm2, 5 min). Scale bar is 50 μm. (K) Statistical results of the percentage of TRPV1+CGRP+ neurons (n=3). Data represent mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001. 'NS' to indicate non-significance.