Abstract
Population carrier screening for cystic fibrosis could soon be a reality, but we know very little about people's attitudes towards genetic disease in general or cystic fibrosis in particular. This paper reports a study which aimed to investigate some of these attitudes and also to explore feelings about CF carrier screening given its practical limitations. The results are discussed in the context of earlier studies which have not raised these practical issues.
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Selected References
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- Cobb E., Holloway S., Elton R., Raeburn J. A. What do young people think about screening for cystic fibrosis? J Med Genet. 1991 May;28(5):322–324. doi: 10.1136/jmg.28.5.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kerem B., Rommens J. M., Buchanan J. A., Markiewicz D., Cox T. K., Chakravarti A., Buchwald M., Tsui L. C. Identification of the cystic fibrosis gene: genetic analysis. Science. 1989 Sep 8;245(4922):1073–1080. doi: 10.1126/science.2570460. [DOI] [PubMed] [Google Scholar]
- Margolin C. R. Attitudes toward control and elimination of genetic defects. Soc Biol. 1978 Spring;25(1):33–37. doi: 10.1080/19485565.1978.9988316. [DOI] [PubMed] [Google Scholar]
- Modell B., Petrou M., Ward R. H., Fairweather D. V., Rodeck C., Varnavides L. A., White J. M. Effect of fetal diagnostic testing on birth-rate of thalassaemia major in Britain. Lancet. 1984 Dec 15;2(8416):1383–1386. doi: 10.1016/s0140-6736(84)92070-1. [DOI] [PubMed] [Google Scholar]
- Riordan J. R., Rommens J. M., Kerem B., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsic N., Chou J. L. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 1989 Sep 8;245(4922):1066–1073. doi: 10.1126/science.2475911. [DOI] [PubMed] [Google Scholar]
- Ten Kate L. P., Tijmstra T. Carrier screening for cystic fibrosis. Lancet. 1989 Oct 21;2(8669):973–974. doi: 10.1016/s0140-6736(89)90975-6. [DOI] [PubMed] [Google Scholar]
- Wilfond B. S., Fost N. The cystic fibrosis gene: medical and social implications for heterozygote detection. JAMA. 1990 May 23;263(20):2777–2783. [PubMed] [Google Scholar]
- Williamson R., Allison M. E., Bentley T. J., Lim S. M., Watson E., Chapple J., Adam S., Boulton M. Community attitudes to cystic fibrosis carrier testing in England: a pilot study. Prenat Diagn. 1989 Oct;9(10):727–734. doi: 10.1002/pd.1970091008. [DOI] [PubMed] [Google Scholar]
- Xamoterol in severe heart failure. The Xamoterol in Severe Heart Failure Study Group. Lancet. 1990 Jul 7;336(8706):1–6. [PubMed] [Google Scholar]