Skip to main content
NCBI home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1992 Oct;29(10):730–732. doi: 10.1136/jmg.29.10.730

The OEIS complex (omphalocele-exstrophy-imperforate anus-spinal defects): recurrence in sibs.

N M Smith 1, H M Chambers 1, M E Furness 1, E A Haan 1
PMCID: PMC1016133  PMID: 1433234

Abstract

The OEIS complex comprises a combination of defects including omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects. It may represent the most severe manifestation of a spectrum of birth defects, the exstrophy-epispadias sequence. The OEIS complex affects 1 in 200,000 to 400,000 pregnancies and is of unknown cause. The purpose of the current report is to document the occurrence of OEIS in sibs from separate pregnancies and suggest that some cases may have a genetic basis.

Full text

PDF
730

Images in this article

731Image
on p.731
731Image
on p.731

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carey J. C., Greenbaum B., Hall B. D. The OEIS complex (omphalocele, exstrophy, imperforate anus, spinal defects). Birth Defects Orig Artic Ser. 1978;14(6B):253–263. [PubMed] [Google Scholar]
  2. Evans J. A., Darvill K. D., Trevenen C., Rockman-Greenberg C. Cloacal exstrophy and related abdominal wall defects in Manitoba: incidence and demographic factors. Clin Genet. 1985 Mar;27(3):241–251. doi: 10.1111/j.1399-0004.1985.tb00215.x. [DOI] [PubMed] [Google Scholar]
  3. Gosden C., Brock D. J. Prenatal diagnosis of exstrophy of the cloaca. Am J Med Genet. 1981;8(1):95–109. doi: 10.1002/ajmg.1320080112. [DOI] [PubMed] [Google Scholar]
  4. HIGGINS C. C. Exstrophy of the bladder: report of 158 cases. Am Surg. 1962 Mar;28:99–102. [PubMed] [Google Scholar]
  5. Hurwitz R. S., Manzoni G. A., Ransley P. G., Stephens F. D. Cloacal exstrophy: a report of 34 cases. J Urol. 1987 Oct;138(4 Pt 2):1060–1064. doi: 10.1016/s0022-5347(17)43502-6. [DOI] [PubMed] [Google Scholar]
  6. Kutzner D. K., Wilson W. G., Hogge W. A. OEIS complex (cloacal exstrophy): prenatal diagnosis in the second trimester. Prenat Diagn. 1988 May;8(4):247–253. doi: 10.1002/pd.1970080402. [DOI] [PubMed] [Google Scholar]
  7. McLaughlin J. F., Marks W. M., Jones G. Prospective management of exstrophy of the cloaca and myelocystocele following prenatal ultrasound recognition of neural tube defects in identical twins. Am J Med Genet. 1984 Dec;19(4):721–727. doi: 10.1002/ajmg.1320190412. [DOI] [PubMed] [Google Scholar]
  8. Redman J. F., Seibert J. J., Page B. C. Cloacal exstrophy in identical twins. Urology. 1981 Jan;17(1):73–74. doi: 10.1016/0090-4295(81)90017-0. [DOI] [PubMed] [Google Scholar]
  9. SPENCER R. EXSTROPHIA SPLANCHNICA (EXSTROPHY OF THE CLOACA). Surgery. 1965 May;57:751–766. [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES