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. 1992 Dec;29(12):858–860. doi: 10.1136/jmg.29.12.858

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

M A Crocq 1, R Mant 1, P Asherson 1, J Williams 1, Y Hode 1, A Mayerova 1, D Collier 1, L Lannfelt 1, P Sokoloff 1, J C Schwartz 1, et al.
PMCID: PMC1016201  PMID: 1362221

Abstract

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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