Skip to main content
NCBI home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1993 Jan;30(1):44–46. doi: 10.1136/jmg.30.1.44

Parental age, genetic mutation, and cerebral palsy.

N A Fletcher 1, J Foley 1
PMCID: PMC1016233  PMID: 8423607

Abstract

Parental age and birth order were studied in 251 patients with cerebral palsy. No parental age or birth order effects were observed in spastic quadriplegia or diplegia, but a paternal age effect was detected in those with athetoid/dystonic cerebral palsy and congenital hemiplegia. These observations indicate that some cases of athetoid/dystonic or hemiplegic cerebral palsy might arise by fresh dominant genetic mutation.

Full text

PDF
44

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADLER E. Familial cerebral palsy. J Chronic Dis. 1961 Mar;13:207–214. doi: 10.1016/0021-9681(61)90077-7. [DOI] [PubMed] [Google Scholar]
  2. ASHER P., SCHONELL F. E. A survey of 400 cases of cerebral palsy in childhood. Arch Dis Child. 1950 Dec;25(124):360–379. doi: 10.1136/adc.25.124.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baar H. S., Gabriel A. M. Sex-linked spastic paraplegia. Am J Ment Defic. 1966 Jul;71(1):13–18. [PubMed] [Google Scholar]
  4. Bundey S., Griffiths M. I. Recurrence risks in families of children with symmetrical spasticity. Dev Med Child Neurol. 1977 Apr;19(2):179–191. doi: 10.1111/j.1469-8749.1977.tb07968.x. [DOI] [PubMed] [Google Scholar]
  5. Fisher R. L., Russman B. S. Genetic syndromes associated with cerebral palsy. Clin Orthop Relat Res. 1974 Mar-Apr;(99):2–11. doi: 10.1097/00003086-197403000-00001. [DOI] [PubMed] [Google Scholar]
  6. Foley J. Dyskinetic and dystonic cerebral palsy and birth. Acta Paediatr. 1992 Jan;81(1):57–94. doi: 10.1111/j.1651-2227.1992.tb12079.x. [DOI] [PubMed] [Google Scholar]
  7. Foley J. The athetoid syndrome. A review of a personal series. J Neurol Neurosurg Psychiatry. 1983 Apr;46(4):289–298. doi: 10.1136/jnnp.46.4.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hall J. G. Genomic imprinting: review and relevance to human diseases. Am J Hum Genet. 1990 May;46(5):857–873. [PMC free article] [PubMed] [Google Scholar]
  9. Kyllerman M., Bager B., Bensch J., Bille B., Olow I., Voss H. Dyskinetic cerebral palsy. I. Clinical categories, associated neurological abnormalities and incidences. Acta Paediatr Scand. 1982 Jul;71(4):543–550. doi: 10.1111/j.1651-2227.1982.tb09472.x. [DOI] [PubMed] [Google Scholar]
  10. Kyllerman M. Dyskinetic cerebral palsy. II. Pathogenetic risk factors and intra-uterine growth. Acta Paediatr Scand. 1982 Jul;71(4):551–558. doi: 10.1111/j.1651-2227.1982.tb09473.x. [DOI] [PubMed] [Google Scholar]
  11. Naeye R. L., Peters E. C., Bartholomew M., Landis J. R. Origins of cerebral palsy. Am J Dis Child. 1989 Oct;143(10):1154–1161. doi: 10.1001/archpedi.1989.02150220044018. [DOI] [PubMed] [Google Scholar]
  12. Nelson K. B., Ellenberg J. H. Antecedents of cerebral palsy. Multivariate analysis of risk. N Engl J Med. 1986 Jul 10;315(2):81–86. doi: 10.1056/NEJM198607103150202. [DOI] [PubMed] [Google Scholar]
  13. PENROSE L. S. Parental age and mutation. Lancet. 1955 Aug 13;269(6885):312–313. doi: 10.1016/s0140-6736(55)92305-9. [DOI] [PubMed] [Google Scholar]
  14. Smith C. A. Note on the estimation of parental age effects. Ann Hum Genet. 1972 Mar;35(3):337–342. doi: 10.1111/j.1469-1809.1957.tb01407.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES