Abstract
Photoacoustic tomography (PAT) is a non-invasive imaging modality that requires recovering the initial data of the wave equation from certain measurements of the solution outside the object. In the standard PAT measurement setup, the used data consist of time-dependent signals measured on an observation surface. In contrast, the measured data from the recently invented full-field detection technique provide the solution of the wave equation on a spatial domain at a single instant in time. While reconstruction using classical PAT data has been extensively studied, not much is known for the full field PAT problem. In this paper, we build mathematical foundations of the latter problem for variable sound speed and settle its uniqueness and stability. Moreover, we introduce an exact inversion method using time-reversal and study its convergence. Our results demonstrate the suitability of both the full field approach and the proposed time-reversal technique for high resolution photoacoustic imaging.
Keywords: full field, photoacoustic tomography, time reversal, uniqueness, stability, Neumann series
AMS subject classifications. 35R30, 35L05, 92C55
1. Introduction.
Consider the following initial value problem for wave equation for an inhomogeneous isotropic medium
| (1.1) |
Here denotes the sound speed and the initial data that is supported inside a bounded domain with Lipschitz boundary. We assume that the sound speed is positive everywhere and constant on the complement of Ω. After rescaling we assume . We refer to the solution of (1.1) as acoustic pressure field and f as the initial pressure.
Recall that is an element of the Sobolev space H1(Ω) if it is Lebesgue measurable and is finite. Also, consists of all elements in H1(Ω) that vanish on the boundary ∂Ω. The space is equipped with the norm , which is equivalent to when restricted to . We note that each can be extended to a function of using the value zero on Ωc, which is tacitly done in this paper.
Full field photoacoustic tomography.
The aim of photoacoustic tomography (PAT) is to recover the initial pressure from certain observations of the acoustic pressure field made outside of Ω. In standard PAT, the data is given by the restricted pressure p|S×[0, T], where is an (n − 1)-dimensional observation surface [28, 38, 9, 20, 4, 19, 11, 30]. Opposed to that, in full field PAT introduced in [26, 27], the data provide the acoustic pressure only for a single and fixed time T but on an n-dimensional measurement domain.
To be more specific, for given T > 0, we define the following two operators
| (1.2) |
| (1.3) |
where p is the solution of (1.1). We refer to WT as the complete single time wave transform and to WT,Ω as the exterior single time wave transform. Full field PAT provides approximations of WT,Ωf, from which one aims to recover approximations to the initial pressure f. In [40] it is outlined how actual full field PAT data can be reduced to WT,Ωf.
In this paper we prove uniqueness and stability of inverting WT,Ω. We also propose a time-reversal technique to derive a Neumann series solution for the inversion.
Related work.
For the standard PAT problem there is a vast literature on various practical and theoretical aspects (see, for example, [38, 20, 4, 19, 11, 30]). In that context, the time-reversal method has been studied intensively [9, 15, 32, 33]. However, to the best of our knowledge, the time-reversal method has not developed for PAT with full field data.
Only few works exist [27, 26, 40, 13] on the full field inversion problem. The work [27] considers constant speed of sound and the problem is reduced to the inversion of the Radon transform. The work [40] deals with non-constant speed and uses the standard Landweber iterative method. However, the article uses the data in the whole space, not the exterior data as we consider here. In the proceeding [13], variational regularization is used with exterior data. Neither uniqueness nor stability has been proven there. In the present article, for the first time, we prove uniqueness and stability for inverting WT,Ω. Moreover, we propose and analyze an iterative time-reversal procedure for its inversion.
2. Uniqueness and stability.
Let be equipped with the metric g = c−2(x)dx2. We denote by diam(Ω) the diameter of Ω, defined as the longest distance between any two points inside with respect to the metric g. We recall that T > 0 is a fixed observation time and a bounded domain with Lipschitz boundary.
2.1. Uniqueness of reconstruction.
Our first aim is to prove the injectivity of WT,Ω, which implies that the full field PAT problem is uniquely solvable. For that purpose we start by recalling a uniqueness result for the wave equation, obtained by Stefanov and Uhlmann [32].
Lemma 2.1. Let and suppose . If the solution p of (1.1) satisfies and , then f = 0.
Denote by the ball of radius R > 0 in the Euclidean metric of . We have the following result:
Lemma 2.2. For ϵ > 0 and , let u ∈ C([0, T], H1(BT+ϵ)) satisfy
| (2.1) |
If h(x) = 0 for x ∈ BT and u(x, T) = 0 for x ∈ Bϵ, then h(x) = 0 for x ∈ BT+ϵ.
Proof. For u satisfying the Euler-Poisson-Darboux equation with initial data (f, 0) instead of the wave equation (2.1), the result was proven in [2, 24]. The proof of the current situation is similar to [24, Theorem 2.1] and is therefore omitted. ■
In the following, for any a > 0, we write
Clearly, for we have , due to finite speed of propagation.
Lemma 2.3. Let Ω be convex, and suppose u satisfies
Then u(x, T) = 0 for all implies h(x) = 0 for all x ∈ Ωc.
Proof. Using Lemma 2.2, the proof follows the lines of [2, Proof of Theorem 3] and for the sake of brevity is omitted. ■
Here is our main uniqueness result.
Theorem 2.4 (Main injectivity result). If T > diam(Ω)/2, then the exterior single time wave transform is injective. In particular, the equation WT,Ωf = g has at most one solution in for .
Proof. Suppose satisfies WT,Ωf = 0 and denote by p the solution of (1.1). By definition we have and thus p(x, T) = 0 and Δp(x, T) = 0 for all x ∈ Ωc. Define u(x, t) ≔ ∂tp(x, T − t). Then in Ωc. Consequently,
Because u(x, T) = ∂tp(x, 0) = 0 in Ωc, Lemma 2.3 shows ∂tp(x, T) = 0 for all x ∈ Ωc. Now application of Lemma 2.1 gives f = 0. ■
2.2. Stability of inversion.
Let us first recall some microlocal analysis for the solution of the wave equation; see for example [32, 37] for more details. Let denote the Fourier transform of f. Let us for the moment assume that there are no two conjugate points within the distance T in (, g). Then, up to infinitely smooth error, the solution p of (1.1) can be written as
| (2.2) |
Here, the phase functions ϕ±(x, ξ, t) are positively homogenous of order 1 in ξ and solve the eikonal equations
The functions a± are classical amplitudes of order 0 satisfying a±(x, ξ, 0) = 1/2. The principal terms satisfy and the homogenous equations
| (2.3) |
where . Geometrically, each singularity (x, ξ) ∈ WF(f) is propagated by p+ in the phase space along the positive bi-characteristic (γx,ξ(t), ζx,ξ(t)), while propagated by p− along the negative bicharacteristic given by (γx,−ξ(t), ζx,−ξ(t)) = (γx,ξ(−t), −ζx,ξ(−t)). Here, the bicharacteristic is defined as the solution of
where |ξ|g is the length of ξ in the metric g. Let us note that the projection γx,ξ(t) of the bicharacteristic is a unit speed geodesic in (, g). Its initial unit tangent vector is ξ/|ξ|g.
We consider the following so-called non-trapping condition.
Condition 2.5 (Non-trapping condition). We assume that there exists T0 > 0 such that there is no geodesic curve that intersects Ω with the length, in metric g, bigger than T0.
It is worth noting that if Condition 2.5 holds then diam(Ω) ≤ T0.
For consider the following time-reversed wave equation
| (2.4) |
We define the time-reversal operator
| (2.5) |
where q is the solution of (2.4). For a function denote by Ψ the pointwise multiplication operator f ↦ Ψf.
Proposition 2.6. Let T > T0/2, suppose and set x±(x, ξ) ≔ γx,ξ(±T). Then is a pseudo-differential operator of order zero with principal symbol
Proof. Our key idea is the construction of the parametrix of time-reversed wave equation (2.4), in the same spirit as [32, Proof of Theorem 3] but adapted to our context. From (2.2), up to smooth terms, we have with
It suffices to prove that is a pseudo-differential operator with principal symbol σ+(x0, ξ0) = Ψ(x+(x0, ξ0))/4, for all (x0, ξ0) ∈ T*Ω.
Consider the parametrix of the time-reversed wave equation (2.4) with initial data , which can be written in the form
with b(x, ξ, T) = Ψ(x)a+(x, ξ, T). Let us note that the first summand in q+ is a modification of the (positive) forward solution p+ which in the case that Ψ = 1 exactly equals p+/2. The second summand is the time-reflection of the first part through the value t = T. This construction imposes zero velocity at t = T. Indeed, it is easy to check that q+ satisfies the initial conditions and (q+)t(x, T) = 0. Therefore, from the definition of ,
| (2.6) |
up to infinitely smoothing terms.
Note that both the principal term and b(0)(x, ξ, t) of a+(x, ξ, t) and b(x, ξ, t), respectively, satisfy the homogeneous transport equation (2.3). Hence, their ratio on each bi-characteristic is constant. In particular,
Let us consider (2.6). Since ϕ+(0, x, ξ) = x · ξ, the first part on the right hand side is a pseudo-differential operator with principal symbol at (x0, ξ0) equals
The second summand of (2.6) is a Fourier integral operator that translates the singularity of f at (γx0,ξ0(−2T), ζx0,ξ0(−2T)) to (x0, ξ0). From the condition T > T0/2, we have γx0, ξ0(−2T) ∈ Ωc. Therefore, f = 0 near γx0,ξ0(−2T), which implies the second part on the right hand side of (2.6) is infinitely smoothing. This concludes our proof. ■
Remark 2.7. Proposition 2.6 has been proven under the assumption that there are no two conjugate points within the distance T in (, g). However, the proposition still holds when this condition fails. In that case, we split the time interval [0, T] into subintervals such that on each subinterval the geodesic γx,ξ(t) does not contain conjugate points. Applying above presented proof iteratively on each subinterval we derive Proposition 2.6 in the general case.
The following theorem provides the stability of solving the final time wave inversion problem.
Theorem 2.8 (Main stability result). Assume that T > T0/2, with T0 as in Condition 2.5. Then, there exists a constant C = C(Ω, T, c) > 0 such that
| (2.7) |
Proof. Since T > T0/2, there exists a > 0 such that for all (x, ξ) ∈ T*Ω either or . Let be such that Ψ ≡ 0 on Ω and Ψ ≡ 1 on . Then ΨWT,Ω = ΨWT and thus Proposition 2.6 implies that is a pseudo-differential operator with principal symbol (Ψ(x+(x, ξ)) + Ψ(x−(x, ξ)))/4 ≥ 1/4. Therefore,
Because is supported inside , we have
Above, the last inequality comes from the conservation of the energy for (2.4) and ∂tq(·,T) ≡ 0. From the last two displayed equations we conclude
| (2.8) |
Since WT,Ω is injective, and the embedding is compact, applying [35, Proposition 5.3.1] to (2.8) concludes the proof. ■
Let us briefly discuss the condition that T > T0/2 posed in Theorem 2.8. It implies for any (x, ξ) ∈ T*Ω, at least either x+(x, ξ) ≔ γx,ξ(T) or x−(x,ξ) ≔ γx,ξ(−T) belongs to Ωc. That is, if (x, ξ) ∈ WF(f) then either (x+(x, ξ), ξ+(x, ξ) ≔ ζx,ξ(t)) ∈ WF(WT,Ωf) or (x−(x, ξ), ξ−(x, ξ) ≔ ζx,−ξ(t)) ∈ WF(WT,Ωf). We, hence, say that all the singularities of f are observed by WT,Ωf. Therefore, T > T0/2 is called the visibility condition. We will always assume it in our subsequent presentation.
3. Iterative time-reversal.
Consider the extension operator defined as follows. For any , we take on Ωc and define EΩ(g) on Ω as the harmonic extension of g to Ω. That is, h ≔ EΩ(g)|Ω satisfies the Dirichlet problem:
| (3.1) |
Here, g|∂Ω ∈ H1/2(∂Ω) denotes the trace of on ∂Ω. Note that the Dirichlet interior problem (3.1) has a unique solution h ∈ H1(Ω) (see, for example, [22]); therefore, noting that EΩ(g) = g on Ωc, . For notational conveniences, we sometimes use the short-hand notation for EΩ(g). We further define the orthogonal projection , where h ∈ H1(Ω) is the solution of (3.1).
Recall that our aim is the inversion of the restricted single time wave inversion operator defined by (1.2). Our proposed inversion approach is based on the modified time-reversal operator defined by
The modified time-reversal operator is itself the composition of harmonic extension EΩ to , time-reversal defined by (2.5) and projection PΩ onto .
3.1. Contraction property.
Consider the case n = 1, the sound speed is constant, and T > T0. Then, from the D’Alembert formula, is the exact inverse of WT,Ω. In the general case this is not true. Nevertheless, as the basis our approach, we will show that the error operator is non-expansive for λ = 2 and a contraction for λ < 2. This will serve as the basis of the proposed iterative time-reversal procedure.
Throughout the following we denote by the energy associated to a function u satisfying the wave equation .
Theorem 3.1 (Contraction property of the error operator). Suppose T > T0/2 and consider for any λ ∈ (0, 2] the error operator
Then the following hold:
KT,Ω,2 satisfies .
If λ ∈ (0, 2), then ∥KT,Ω,λ∥ < 1.
Proof. (a): For , set g ≔ WT,Ωf and . That is, and , where p solves the forward problem (1.1). Let and q solve the time-reversal problem (2.4) with . Then w ≔ p − q satisfies the wave equation and the corresponding energies at times 0 and T respectively satisfy
| (3.2) |
Since and ,
That is, . Noting that on Ωc, we obtain . From (3.2) we deduce Ew(T) = Ep(T). With the conservation of energy we have Ep(0) = Ew(0) and therefore
| (3.3) |
where we have used the explicit expressions for Ep(0) and Ew(0) respectively.
With the error operator satisfies KT,Ω,2f = f − f*. Moreover, writing q0 ≔ q(·,0)|Ω we have f* = PΩ(q0) and thus Δ[q0 − f*] = 0 in Ω. From this we infer and therefore
| (3.4) |
Together with (3.3) this implies . That is, .
In remains to show the strict inequality. To that end assume . From (3.3) and (3.4) we obtain
and therefore
In particular, ∂tq(·,0) vanishes on and ∇q(·,0) vanishes on Ωc. Because q(x, 0) vanishes for , it follows that q(·,0) vanishes on Ωc. Applying Lemma 2.1 for u(·,t) ≔ q(·,T −t) yields on . In particular, WT,Ωf = 0 on Ωc. From Theorem 2.4, we infer f = 0 on , which concludes the proof.
(b): Let us first consider the case λ = 1. We have to show that there exists a constant L < 1 such that . To that end, let , p solve the forward model (1.1) with initial data f, q solve the time-reversal problem (2.4) with initial data h = EΩWT,Ωf and define the error term w ≔ q − p. The error term satisfies the wave equation in and its energy at time T is given by
where for the second equality we used the conditions and ∂tg(·,T) = 0. The functions and are defined as above, in the proof of (a).
The second term in the above equation displayed satisfies
As a consequence, recalling , we obtain
The conservation of energy for E and p then gives
Using the initial conditions p(x, 0) = f(x) and ∂tp(x, 0) = 0 this shows
Noting that WT,Ωf vanishes outside of , we have , for some μ > 0. Applying Theorem 2.8 we obtain
for some 0 < L < 1. Noting that , we obtain
| (3.5) |
Let and q0 = q(·,0)|Ω, then f* = PΩ(q0). The left hand side in the above equation can be estimated as
where we have used the fact that . From 3.5, we arrive at
This finishes the proof for the case λ = 1.
For the general case note the identities
Using the already verified estimates ∥KT,Ω,1∥ < 1 and ∥KT,Ω,2∥ ≤ 1, these equalities together with the triangle inequality for the operator norm show ∥KT,Ω,λ∥ < 1 for all λ ∈ (0, 2). ■
3.2. Neumann series solution.
According to Theorem 3.1 the error operator satisfies for any λ ∈ (0, 2). The Neumann series , therefore, converges to with respect to the operator norm ∥·∥ in . This results in the inversion formula
| (3.6) |
valid for every initial data . Here is the modified time-reversal operator formed by harmonic extension EΩ of the missing data, time-reversal defined by (2.4) and projection PΩ onto . Inversion formula (3.6) is the Neumann series solution for the inverse problem of full-field PAT.
Remark 3.2 (Iterative time-reversal algorithm). The Neumann series in (3.6) is the limit of its partial sums . These partial sums satisfy the recursion
| (3.7) |
with . This is an iterative algorithm producing a sequence converging to in . We call (3.7) iterative reversal algorithm for full field PAT. The form (3.7) will be used in the numerical solution. Because of the contraction property of the iteration the iterative time-reversal reversal algorithm is linearly convergent.
We note that for standard PAT, the idea of using time-reversal was proposed in [9, 7] for the case of constant sound speed, and in [10, 15] for non-constant sound speed. The Neumann series solution was first proposed in [32] and further developed in [32, 33, 36, 14, 34, 25, 29, 18, 1]. Iterative reconstruction methods for variable sound speed based on an adjoint wave equation have been studied in [16, 5, 3, 11, 17]. Uniqueness and stability for standard PAT was studied in [39, 15, 32, 33, 23], just to name a few.
4. Numerical Simulations.
In this section, we present some of our numerical studies for the exterior single time wave transform. We consider the case of two spatial dimensions, and take as the unit disc. According to (3.6) any function can be recovered from data g = WT,Ωf via the iterative time-reversal algorithm (3.7). The numerical realization is described in the following subsection. The numerical simulations were performed for each of the three sound speed profiles shown in the top row of Figure 1 and additionally for the constant sound speed cI = 1. The sound speed profiles cIII and cIV are adopted from [31] where cIII is shown to be trapping and cIV to be non-trapping. For the used radially symmetric sound speed profile cIII = c(∥x∥) the Herglotz condition is satisfied which implies that cIII is non-trapping. As phantom we used numerical approximations of one smooth and two piecewise constant functions which are visualized in the bottom row of Figure 1.
Figure 1. Sound speeds profiles and initial pressure distributions.

Top: Three non-trapping (cII and cIII) and one trapping sound speed profile cIV that we employed in our simulations besides the constant speed of sound cI = 1. The white and black circles visualize the boundary of the imaging region which in our simulations is the unit disc. Bottom: A smooth phantom fa (left) and the two piecewise constant phantoms fb (middle) and fc (right) are employed in our numerical simulations.
4.1. Numerical implementation.
In the numerical realization, any function is represented by a discrete vector , where
are equidistant grid points in the square [−a, a]2. The discrete domain I ⊆ {0, …, N − 1}2 (where the discrete initial pressure is contained in) is defined as the set of all indices i with xi ∈ Ω and we set J ≔ {0, …, N − 1}2 \ I. Following [12], we define the discrete boundary of I as the set of all elements (i1, i2) ∈ J for which at least one of the discrete neighbors (i1 + 1, i2),(i1 − 1, i2),(i1, i2 + 1), (i1, i2 − 1) is contained in I. The discrete version of the initial data is then an image and the discrete version of the data an image .
In the iterative time-reversal algorithm the forward transform WT,Ω as well as each factor in the modified time-reversal are replaced by discrete approximations. The discrete forward operator and the discrete time-reversal operator are defined by
| (4.1) |
| (4.2) |
Here and are discrete analogs of the forward wave equation and its time reversed version, EI a discretization of the harmonic extension operator and PI a discretization of the projection of the projection onto .
The numerical solution of the wave equation WT f and likewise the numerical solution of the time reversed version are computed with the k-space method [6, 8, 21]. We use the k-space method with periodic boundary conditions on the rectangle [−a, a]2 as described in [11]. We choose a ≥ T +1 such that WT,I and are not affected by replacing the free space wave equation with its (2a)-periodic counterpart. The discrete harmonic extension EI and the discrete projection PI are constructed by numerically solving (3.1) with the MATLAB-routine solvepde.
4.2. Numerical results.
We first present results for data g = WT f without added noise. Figure 2 shows results with constant speed with relaxation parameter λ = 2 and 80 iterations. For smaller values of λ slightly better reconstructions have been obtained but required a slightly larger number of iterations. Figure 3 visualizes the pointwise error map for the non-constant sound speed profiles using λ = 1/2 and T = 2. We see that accurate results are obtained for all sound speed profiles. The best results were obtained for the sound speed profile cII, and the error functions do not contain any visible information of the original phantom. Because all reconstructions look equally well and very similar to the original phantom fa, we did not show them here. Additional simulations with other smooth and non-smooth phantoms indicate that smooth phantoms generally result in better reconstructions than non-smooth ones.
Figure 2. Results for constant sound speed.

Reconstructions (top) and corresponding point-wise errors (bottom) using constant sound speed cI = 1.
Figure 3. Results for variable sound speed.

Point-wise errors (bottom) using different sound speed profiles and the smooth phantom fa.
Next, in Figure 4, we present results for noisy data where has been contaminated with normally distributed noise with a standard deviation δ of two percent of the maximal pressure value. In order to avoid inverse crime, data are simulated using a three times finer discretization than used for the reconstruction. We observe that in all cases the iteration process is stable when λ is chosen sufficiently small, i.e. 0 < λ ≤ 1/2, and the use of a stopping rule is not necessary. Moreover, the reconstructions are more accurate for smooth phantoms than for piecewise constant phantoms. Finally in Figure 5 we show results for the trapping sound speed cIV. Also in this case, the iterative time-reversal works well for all phantoms even though the theory developed in the previous Sections does not fully apply in this situation.
Figure 4. Exact versus noisy data for sound speed cIII.

From left to right: reconstruction, difference images to true phantom fa, and logarithmic error plot in dependence of the number of iterations. The top row shows results for exact data, the bottom row shows results for noisy data with standard deviation δ = 0.02. Here λ = 1/2 and T = 4. In this example, the observation time is twice as large as for the example in Fig 3, i.e. we have more data. This leads to a much smaller pointwise error for zero noise.
Figure 5. Results for noisy data for trapping sound speed cIV.

Top row shows the reconstructions of the phantom fa, fb and fc. Bottom row: Corresponding difference images for to the true phantom. Here λ = 1/2 and T = 2
5. Conclusion.
In this work we studied an inverse source problem appearing in full field PAT. Image reconstruction amounts to the inversion of the exterior final time wave transform WT,Ω that maps the initial data f supported in Ω to the solution of the wave equation at fixed time T restricted to the complement . For non-constant sound speed, besides the work [13], to the best of our knowledge, inversion of WT,Ω is studied for the first time. We, for the first time, derived uniqueness and stability results. Moreover we showed convergence of the proposed iterative time-reversal reconstruction algorithm. For that purpose we have proven that is a contraction on for all λ ∈ (0, 2) where is a modified time-reversal operator. We also derived a numerical realization of the iterative time-reversal algorithm. Numerical results show accurate reconstruction for all sound speed profiles and all initial data.
Acknowledgments.
The authors would like to thank the anonymous referees for the helpful comments and suggestions. M.H. acknowledges support of the Austrian Science Fund (FWF), project P 30747-N32. The research of L.N. has been supported by the National Science Foundation (NSF) Grants DMS 1212125 and DMS 1616904. L.N.’s research reported in this publication was also supported by the National Institute Of General Medical Sciences of the National Institutes of Health under Award Number P20GM104420. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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