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. 1993 Mar;30(3):202–205. doi: 10.1136/jmg.30.3.202

Mapping of the X linked form of hyper IgM syndrome (HIGM1)

M Padayachee 1, R J Levinsky 1, C Kinnon 1, A Finn 1, C McKeown 1, C Feighery 1, L D Notarangelo 1, R W Hendriks 1, A P Read 1, S Malcolm 1
PMCID: PMC1016299  PMID: 8097258

Abstract

X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.

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Selected References

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