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[Preprint]. 2023 Apr 29:2023.04.28.538728. [Version 1] doi: 10.1101/2023.04.28.538728

Figure 1: Evaluation of microglia composition and amyloid pathology across CA1 in WT and APP/PS1 mice.

Figure 1:

(A) Experimental outline (see Methods for additional details).

(B) IBA1+ microglia from B6.APP/PS1 TG control and PLX5622 mice (left). Quantification of IBA1+/DAPI+ microglia across CA1 lamina (right). Datapoints represent individual mice; error bars are ± SD; asterisks denote comparisons (p<0.05) identified between control and PLX5622 groups (right) after corrections for multiple comparisons. SLM, stratum lacunosum moleculare; SR, stratum radiatum; SO, stratum oriens.

(C) X34+ Aβ plaques in B6.APP/PS1 TG control and PLX5622 mice (left). Quantification of X34+ Aβ plaque area across CA1 lamina (right), plotted as described above.

(D) Quantification of IBA1+ area from SLM defined as plaque-associated (PAM) or non-plaque associated microglia (NPAM). Points represent mean values calculated for individual mice and analyzed with two-tailed nonparametric t-tests.

Statistical analyses performed on B6 and PWK separately. For (B)-(C) *adjusted p<0.05 Bonferroni post-hoc tests. For (D) *p<0.05 nonparametric two-tailed t-test (Table S2).