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The table shows the average number of genome-wide significant variants (“GWV”, p-value ≤5e-8) per 100 replicates, and the median MAF of these variants in the scenario of extremely imbalanced case-control ratio. The MAF of variants identified by Tractor is computed based on local ancestry dosage.
| 100 replicates | GMMAT | SAIGE | Tractor | |
|---|---|---|---|---|
| Major ancestry | Minor ancestry | |||
| # of GWV | 0.66 | 0 | 1.36 | 3.80 |
| Median MAF | 0.0009 | NA | 0.0034 | 0.0073 |
