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. 1990 Feb;27(2):101–104. doi: 10.1136/jmg.27.2.101

Carrier estimations in Duchenne muscular dystrophy families in Northern Ireland using RFLP analysis.

E D Kelly 1, C A Graham 1, A J Hill 1, N C Nevin 1
PMCID: PMC1016929  PMID: 1969486

Abstract

Intragenic RFLP analysis was used to provide carrier risk estimations on 100 possible female carriers from 22 Duchenne muscular dystrophy families. This enabled 78% of possible carriers to be assigned high or low risks (greater than 90% or less than 10%) as opposed to 26% assigned low risk on pedigree data alone. When a single polymorphism is not informative the use of haplotype analysis for carrier estimations is illustrated for one family.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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