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. 1990 Feb;27(2):130–132. doi: 10.1136/jmg.27.2.130

Neuroblastoma in a patient with Sotos' syndrome.

M A Nance 1, J P Neglia 1, D Talwar 1, S A Berry 1
PMCID: PMC1016935  PMID: 2319581

Abstract

Sotos' syndrome, or cerebral gigantism, is a disorder of growth regulation. Tumours have occasionally been reported in children with Sotos' syndrome, but it is uncertain whether this is a coincidence, or whether it is aetiologically related to the underlying disorder of growth. We report a 15 month old child with a paraspinal neuroblastoma and Sotos' syndrome and suggest that children with this condition may be at higher risk for developing tumours than the general population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham J. M., Snodgrass G. J. Sotos' syndrome of cerebral gigantism. Arch Dis Child. 1969 Apr;44(234):203–210. doi: 10.1136/adc.44.234.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bale A. E., Drum M. A., Parry D. M., Mulvihill J. J. Familial Sotos syndrome (cerebral gigantism): craniofacial and psychological characteristics. Am J Med Genet. 1985 Apr;20(4):613–624. doi: 10.1002/ajmg.1320200407. [DOI] [PubMed] [Google Scholar]
  3. Daling J. R., Starzyk P., Olshan A. F., Weiss N. S. Birth weight and the incidence of childhood cancer. J Natl Cancer Inst. 1984 May;72(5):1039–1041. [PubMed] [Google Scholar]
  4. Dodge P. R., Holmes S. J., Sotos J. F. Cerebral gigantism. Dev Med Child Neurol. 1983 Apr;25(2):248–252. doi: 10.1111/j.1469-8749.1983.tb13750.x. [DOI] [PubMed] [Google Scholar]
  5. Evans P. R. Sotos' syndrome (cerebral gigantism) with peripheral dysostosis. Arch Dis Child. 1971 Apr;46(246):199–202. doi: 10.1136/adc.46.246.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Flaggert J. J., 3rd, Heldt L. V., Gareis F. J. Recurrent giant cell granuloma occurring in the mandible of a patient on high dose estrogen therapy for the treatment of Sotos' syndrome. J Oral Maxillofac Surg. 1987 Dec;45(12):1074–1076. doi: 10.1016/0278-2391(87)90169-8. [DOI] [PubMed] [Google Scholar]
  7. Hook E. B., Reynolds J. W. Cerebral gigantism: endocrinological and clinical observations of six patients including a congenital giant, concordant monozygotic twins, and a child who acheived adult gigantic size. J Pediatr. 1967 Jun;70(6):900–914. doi: 10.1016/s0022-3476(67)80263-4. [DOI] [PubMed] [Google Scholar]
  8. Maldonado V., Gaynon P. S., Poznanski A. K. Cerebral gigantism associated with Wilms' tumor. Am J Dis Child. 1984 May;138(5):486–488. doi: 10.1001/archpedi.1984.02140430062016. [DOI] [PubMed] [Google Scholar]
  9. Neglia J. P., Smithson W. A., Gunderson P., King F. L., Singher L. J., Robison L. L. Prenatal and perinatal risk factors for neuroblastoma. A case-control study. Cancer. 1988 Jun 1;61(11):2202–2206. doi: 10.1002/1097-0142(19880601)61:11<2202::aid-cncr2820611113>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  10. SOTOS J. F., DODGE P. R., MUIRHEAD D., CRAWFORD J. D., TALBOT N. B. CEREBRAL GIGANTISM IN CHILDHOOD. A SYNDROME OF EXCESSIVELY RAPID GROWTH AND ACROMEGALIC FEATURES AND A NONPROGRESSIVE NEUROLOGIC DISORDER. N Engl J Med. 1964 Jul 16;271:109–116. doi: 10.1056/NEJM196407162710301. [DOI] [PubMed] [Google Scholar]
  11. Seyedabadi S., Bard D. S., Zuna R. E., Schedewie H., Araoz C., Elders M. J. Epidermoid carcinoma of the vagina in a patient with cerebral gigantism. J Ark Med Soc. 1981 Aug;78(3):123–127. [PubMed] [Google Scholar]
  12. Warrier R. P., Kini R., Besser A., Wiatrak B., Raju U. Opsomyoclonus and neuroblastoma. Clin Pediatr (Phila) 1985 Jan;24(1):32–34. doi: 10.1177/000992288502400106. [DOI] [PubMed] [Google Scholar]
  13. Whitaker M. D., Scheithauer B. W., Hayles A. B., Okazaki H. The hypothalamus and pituitary in cerebral gigantism. A clinicopathologic and immunocytochemical study. Am J Dis Child. 1985 Jul;139(7):679–682. doi: 10.1001/archpedi.1985.02140090041023. [DOI] [PubMed] [Google Scholar]
  14. Wit J. M., Beemer F. A., Barth P. G., Oorthuys J. W., Dijkstra P. F., Van den Brande J. L., Leschot N. J. Cerebral gigantism (Sotos syndrome). Compiled data of 22 cases. Analysis of clinical features, growth and plasma somatomedin. Eur J Pediatr. 1985 Jul;144(2):131–140. doi: 10.1007/BF00451898. [DOI] [PubMed] [Google Scholar]

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