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. 2022 Jul 22;146(2):749–766. doi: 10.1093/brain/awac266

Figure 1.

Figure 1

Top 25 pain-associated genes in the male cohort (increased in pain). Pain-associated genes in male samples (Supplementary Table 3A) show systematic increases in pain. Quantile plots (quantile versus value) for gene relative abundances (in TPMs) for the top 25 genes are shown in male pain samples (in red, upper line) and male no-pain samples (in blue, lower line). These include multiple members of AP-1 signalling (EGR3, FOSL1), pro-inflammatory cytokines (IL1B, CCL3, CCL4), TNF signalling (TNF, IL1B) and other transcriptional regulators (NR4A2, FOXS1, HBEGF) relevant to the peripheral nervous system and pain.