Skip to main content
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1990 Apr;27(4):273–274. doi: 10.1136/jmg.27.4.273

Fetal brain disruption sequence: a milder variant.

C G Bönnemann 1, P Meinecke 1
PMCID: PMC1017035  PMID: 2325109

Abstract

We report on a female infant with severe microcephaly, scalp rugae, overlapping sutures, and telancephalic damage with relatively satisfactory early motor development. This case represents a milder form of the 'fetal brain disruption sequence', which is thought to be the result of an exogenous insult to the developing brain during the second half of gestation.

Full text

PDF
273

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin S., Whitley R. J. Intrauterine herpes simplex virus infection. Teratology. 1989 Jan;39(1):1–10. doi: 10.1002/tera.1420390102. [DOI] [PubMed] [Google Scholar]
  2. Russell L. J., Weaver D. D., Bull M. J., Weinbaum M. In utero brain destruction resulting in collapse of the fetal skull, microcephaly, scalp rugae, and neurologic impairment: the fetal brain disruption sequence. Am J Med Genet. 1984 Feb;17(2):509–521. doi: 10.1002/ajmg.1320170213. [DOI] [PubMed] [Google Scholar]
  3. Tolmie J. L., McNay M., Stephenson J. B., Doyle D., Connor J. M. Microcephaly: genetic counselling and antenatal diagnosis after the birth of an affected child. Am J Med Genet. 1987 Jul;27(3):583–594. doi: 10.1002/ajmg.1320270311. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES