Abstract
The effect of consanguinity on fetal growth and development was studied in 3700 consecutive births (live and stillborn); 26% of the total births were to consanguineous couples. Hindus had a higher frequency of consanguineous marriages, uncle-niece unions being the commonest type, whereas Moslems preferred first cousin marriages. The incidence of congenital malformations was 39.1/1000 births with a significantly higher incidence among the consanguineous group (8.01%) as against the nonconsanguineous group (2.42%) (p less than 0.001). The incidence of malformations was higher in the uncle-niece matings (9.34%) compared to the first cousin marriages (6.18%) (p less than 0.01). Malformations of major systems were significantly more frequent among the consanguineous couples, whereas malformations of the eyes, ears, and skin did not show any significant effect of consanguinity. Stillbirth rates were significantly higher in the consanguineous group, irrespective of the mother's socioeconomic status, and were higher in uncle-niece matings compared to first cousin and beyond first cousin unions in both the poor and middle/upper class. A significant decrease in the mean birth weight and head circumference of babies born to consanguineous parents was noted in both the poor and middle/upper socioeconomic class. The mean length was less in babies born to consanguineous parents belonging to the poor social class only.
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- Jeffreys A. J., Wilson V., Thein S. L. Individual-specific 'fingerprints' of human DNA. Nature. 1985 Jul 4;316(6023):76–79. doi: 10.1038/316076a0. [DOI] [PubMed] [Google Scholar]
- Kulkarni M. L., Mathew M. A., Reddy V. The range of neural tube defects in southern India. Arch Dis Child. 1989 Feb;64(2):201–204. doi: 10.1136/adc.64.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kulshrestha R., Nath L. M., Upadhyaya P. Congenital malformations in live born infants in a rural community. Indian Pediatr. 1983 Jan;20(1):45–49. [PubMed] [Google Scholar]
- Naderi S. Congenital abnormalities in newborns of consanguineous and nonconsanguineous parents. Obstet Gynecol. 1979 Feb;53(2):195–199. [PubMed] [Google Scholar]
- Paddaiah G., Reddy G. G. Effect of consanguinity on anthropometric measurements in the newborn. Indian J Pediatr. 1980 Mar-Apr;47(385):133–136. doi: 10.1007/BF02822878. [DOI] [PubMed] [Google Scholar]
- Prosad B. G. Changes proposed in the social classification of Indian families. J Indian Med Assoc. 1970 Sep 16;55(6):198–199. [PubMed] [Google Scholar]
- Radha Rama Devi A., Rao N. A., Bittles A. H. Inbreeding in the state of Karnataka, South India. Hum Hered. 1982;32(1):8–10. doi: 10.1159/000153252. [DOI] [PubMed] [Google Scholar]
- Rao P. S., Inbaraj S. G. Inbreeding effects on fetal growth and development. J Med Genet. 1980 Feb;17(1):27–33. doi: 10.1136/jmg.17.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanghvi L. D. Inbreeding in India. Eugen Q. 1966 Dec;13(4):291–301. doi: 10.1080/19485565.1966.9987682. [DOI] [PubMed] [Google Scholar]
- Sibert J. R., Jadhav M., Inbaraj S. G. Fetal growth and parental consanguinity. Arch Dis Child. 1979 Apr;54(4):317–319. doi: 10.1136/adc.54.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smithells R. W., Sheppard S., Schorah C. J. Vitamin deficiencies and neural tube defects. Arch Dis Child. 1976 Dec;51(12):944–950. doi: 10.1136/adc.51.12.944. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stevenson A. C., Johnston H. A., Stewart M. I., Golding D. R. Congenital malformations. A report of a study of series of consecutive births in 24 centres. Bull World Health Organ. 1966;34 (Suppl):9–127. [PMC free article] [PubMed] [Google Scholar]
- Verma I. C. High frequency of neural-tube defects in North India. Lancet. 1978 Apr 22;1(8069):879–880. doi: 10.1016/s0140-6736(78)90225-8. [DOI] [PubMed] [Google Scholar]