Abstract
The blood-retinal barrier plays an important part in the processes of retinal pathophysiology. A new clinical method for the study of the blood-retinal barrier by vitreous fluorophotometry appears to satisfy the necessary requirements in that it is quantitative and shows good reproducibility and high sensitivity. The application of this method to a series of diabetic patients with apparently "normal" fundi revealed the presence of a significant breakdown of the blood-retinal barrier in the early stages of retinal involvement in diabetes. The extent of the breakdown can be measured allowing for comparative and evolutionary evaluations. The disturbance of the blood-retinal barrier, as evidence by vitreous fluorophotometry, appears before microaneurysms or capillary closure can be demonstrated by fluorescein angiography.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashton N. Bowman lecture. The blood-retinal barrier and vaso-glial relationships in retinal disease. Trans Ophthalmol Soc U K. 1965;85:199–230. [PubMed] [Google Scholar]
- Ben-Sira I., Riva C. E. Fluorophotometric recording of fluorescein dilution curves in human retinal vessels. Invest Ophthalmol. 1973 Apr;12(4):310–312. [PubMed] [Google Scholar]
- Cunha-Vaz J. G., Maurice D. M. The active transport of fluorescein by the retinal vessels and the retina. J Physiol. 1967 Aug;191(3):467–486. doi: 10.1113/jphysiol.1967.sp008262. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waltman S. R., Kaufman H. E. A new objective slit lamp fluorophotometer. Invest Ophthalmol. 1970 Apr;9(4):247–249. [PubMed] [Google Scholar]