Abstract
Benzalkonium chloride, a surface-active preservative commonly used in eyedrop preparations, has been shown to hasten the drying of the precorneal tear film. In the rabbit, 0.01 per cent benzalkonium (the concentration usually employed as a preservative) shortened the time required for the appearance of dry spots on the corneal surface by a factor of about four. In man, an approximately twofold hastening was demonstrated. This effect is thought to preclude the use of this substance as a preservative in eyedrop preparations for use as local anaesthetics.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Iwata S., Lemp M. A., Holly F. J., Dohlman C. H. Evaporation rate of water from the precorneal tear film and cornea in the rabbit. Invest Ophthalmol. 1969 Dec;8(6):613–619. [PubMed] [Google Scholar]
- Lemp M. A., Goldberg M., Roddy M. R. The effect of tear substitutes on tear film break-up time. Invest Ophthalmol. 1975 Mar;14(3):255–258. [PubMed] [Google Scholar]
- MISHIMA S., MAURICE D. M. The oily layer of the tear film and evaporation from the corneal surface. Exp Eye Res. 1961 Sep;1:39–45. doi: 10.1016/s0014-4835(61)80006-7. [DOI] [PubMed] [Google Scholar]