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. 1975 Dec;59(12):696–698. doi: 10.1136/bjo.59.12.696

Opsoclonus. Pattern of regression in a child with neuroblastoma.

P J Savino, J S Glaser
PMCID: PMC1017437  PMID: 1240767

Abstract

A child with opsoclonus associated with occult neuroblastoma is presented, in whom regression of the eye movement disorder through phases of flutter and dysmetria was observed. It is speculated that these ocular motor abnormalities represent a continuum of cerebellar dysfunction. A peculiar dysmetric head movemment not related to saccadic palsy is documented.

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Selected References

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  1. Bray P. F., Ziter F. A., Lahey M. E., Myers G. G. The coincidence of neuroblastoma and acute cerebellar encephalopathy. J Pediatr. 1969 Dec;75(6):983–990. doi: 10.1016/s0022-3476(69)80335-5. [DOI] [PubMed] [Google Scholar]
  2. COGAN D. G. A type of congenital ocular motor apraxia presenting jerky head movements. Trans Am Acad Ophthalmol Otolaryngol. 1952 Nov-Dec;56(6):853–862. [PubMed] [Google Scholar]
  3. Cushing H., Wolbach S. B. The Transformation of a Malignant Paravertebral Sympathicoblastoma into a Benign Ganglioneuroma. Am J Pathol. 1927 May;3(3):203–216.7. [PMC free article] [PubMed] [Google Scholar]
  4. Ellenberger C., Jr, Campa J. F., Netsky M. G. Opsoclonus and parenchymatous degeneration of the cerebellum. The cerebellar origin of an abnormal ocular movement. Neurology. 1968 Nov;18(11):1041–1046. doi: 10.1212/wnl.18.11.1041. [DOI] [PubMed] [Google Scholar]
  5. Ellenberger C., Jr, Keltner J. L., Stroud M. H. Ocular dyskinesia in cerebellar disease. Evidence for the similarity of opsoclonus, ocular dysmetria and flutter-like oscillations. Brain. 1972;95(4):685–692. doi: 10.1093/brain/95.4.685. [DOI] [PubMed] [Google Scholar]
  6. Keane J. R., Devereaux M. W. Opsoclonus associated with an intracranial tumor. A clinicopathologic case report. Arch Ophthalmol. 1974 Nov;92(5):443–445. doi: 10.1001/archopht.1974.01010010455017. [DOI] [PubMed] [Google Scholar]
  7. Larbre F., Bethenod M., Guibaud P., Mamelle J. C., Genoud J. Syndrome oculo-cerebello-myoclonique et neuroblastome. A propos de deux observations. Arch Fr Pediatr. 1972 Apr;29(4):411–420. [PubMed] [Google Scholar]
  8. Miller R. W. Fifty-two forms of childhood cancer: United States mortality experience, 1960-1966. J Pediatr. 1969 Oct;75(4):685–689. doi: 10.1016/s0022-3476(69)80466-x. [DOI] [PubMed] [Google Scholar]
  9. Moe P. G., Nellhaus G. Infantile polymyoclonia-opsoclonus syndrome and neural crest tumors. Neurology. 1970 Aug;20(8):756–764. doi: 10.1212/wnl.20.8.756. [DOI] [PubMed] [Google Scholar]
  10. Ross A. T., Zeman W. Opsoclonus, occult carcinoma, and chemical pathology in dentate nuclei. Arch Neurol. 1967 Nov;17(5):546–551. doi: 10.1001/archneur.1967.00470290100013. [DOI] [PubMed] [Google Scholar]
  11. SMITH J. L., WALSH F. B. Opsoclonus-ataxic conjugate movements of the eyes. Arch Ophthalmol. 1960 Aug;64:244–250. doi: 10.1001/archopht.1960.01840010246010. [DOI] [PubMed] [Google Scholar]
  12. Senelick R. C., Bray P. F., Lahey M. E., VanDyk H. J., Johnson D. G. Neuroblastoma and myoclonic encephalopathy: two cases and a review of the literature. J Pediatr Surg. 1973 Oct;8(5):623–632. doi: 10.1016/0022-3468(73)90400-4. [DOI] [PubMed] [Google Scholar]
  13. Solomon G. E., Chutorian A. M. Opsoclonus and occult neuroblastoma. N Engl J Med. 1968 Aug 29;279(9):475–477. doi: 10.1056/NEJM196808292790907. [DOI] [PubMed] [Google Scholar]

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