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. 1976 Apr;60(4):236–244. doi: 10.1136/bjo.60.4.236

Effects of fast neutrons on the eye.

J Roth, N Brown, M Catterall, A Beal
PMCID: PMC1017484  PMID: 1276111

Abstract

The study of 93 eyes receiving neutron irradiation establishes the character of the ophthalmic complications of neutron. Significant changes are produced in the eyelids, conjunctiva, and cornea, but the production of cataract is relatively unimportant. No reaction was seen after neutron treatment that had not already been seen after chi or gamma radiation. That the unavoidable damage is similar to that reported with other forms of radiation, and not worse, is an important finding in view of the statistically significant benefit of neutron treatment to patients in a controlled clinical trial of advanced tumours of the head and neck (Catterall and others, 1975). The observations indicate that the improved cure rates with neutrons are not obtained at the expense of inflicting greater damage to normal structures. This investigation has also shown that the neutron effects of treating these very extensive tumours are acceptable and that, with carefully measured doses, they are predictable. The dose-response relationship in categories of clinical effect for a smaller series of patients, reported in Table 1 of our preliminary communication (Brown and other, 1976), is confirmed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELSON P. H., KRUGER P. G. Cyclotron-induced radiation cataracts. Science. 1949 Dec 16;110(2868):655–657. doi: 10.1126/science.110.2868.655. [DOI] [PubMed] [Google Scholar]
  2. BAILY N. A., NOELL W. K. Relative biological effectiveness of various qualities of radiation as determined by the electroretinogram. Radiat Res. 1958 Oct;9(4):459–468. [PubMed] [Google Scholar]
  3. BLODI F. C. The late effects of x-radiation on the cornea. Trans Am Ophthalmol Soc. 1958;56:413–450. [PMC free article] [PubMed] [Google Scholar]
  4. Bedford M. A. The corneal and conjunctival complications following radiotherapy. Proc R Soc Med. 1966 Jun;59(6):529–530. doi: 10.1177/003591576605900620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown N. Quantitative slit-image photography of the lens. Trans Ophthalmol Soc U K. 1972;92:303–307. [PubMed] [Google Scholar]
  6. CIBIS P. A., BROWN D. V. Retinal changes following ionizing radiation. Am J Ophthalmol. 1955 Nov;40(5 Pt 2):84–88. doi: 10.1016/0002-9394(55)91840-7. [DOI] [PubMed] [Google Scholar]
  7. CIBIS P. A., NOELL W. K., EICHEL B. Ocular effects produced by high-intensity x-radiation. AMA Arch Ophthalmol. 1955 May;53(5):651–663. doi: 10.1001/archopht.1955.00930010659006. [DOI] [PubMed] [Google Scholar]
  8. COGAN D. G., GOFF J. L., GRAVES E. Experimental radiation cataract. II. Cataract in the rabbit following single exposure to fast neutrons. AMA Arch Ophthalmol. 1952 May;47(5):584–592. [PubMed] [Google Scholar]
  9. Catterall M., Sutherland I., Bewley D. K. First results of a randomized clinical trial of fast neutrons compared with X or gamma rays in treatment of advanced tumours of the head and neck. Report to the Medical Research Council. Br Med J. 1975 Jun 21;2(5972):653–656. doi: 10.1136/bmj.2.5972.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Catterall M., Vonberg D. D. Treatment of advanced tumours of head and neck with fast neutrons. Br Med J. 1974 Jul 20;3(5924):137–143. doi: 10.1136/bmj.3.5924.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Goldstein J. H., Hornblass A., Clahane A. C. Effect of peripheral vision on the binocular relationship: a further study. Am J Ophthalmol. 1968 Jul;66(1):86–89. doi: 10.1016/0002-9394(68)91793-5. [DOI] [PubMed] [Google Scholar]
  12. Haye C., Legeay G., Bazin J. P., Quechon H. Influence de la dose d'irradiation sur le temps de latence de la cataracte du lapin. Determination de l'efficacite biologique relative des neutrons de 14 MeV. Ann Ocul (Paris) 1970 Aug;203(8):749–767. [PubMed] [Google Scholar]
  13. Haye C., Mathe G., Jammet H., Pendic B. Cataracte d'origine atomique secondaire à l'irradiation totale aiguë accidentelle survenue en Yougoslavie en 1958. Arch Ophtalmol Rev Gen Ophtalmol. 1970 Aug-Sep;30(8):567–570. [PubMed] [Google Scholar]
  14. KRAUSE A. C., BOND J. O. Neutron cataracts. Am J Ophthalmol. 1951 Jan;34(1):25–35. doi: 10.1016/0002-9394(51)91924-1. [DOI] [PubMed] [Google Scholar]
  15. Linnell P. C., Wolter J. R. Corneal necrosis after x-ray treatment. Eye Ear Nose Throat Mon. 1967 Mar;46(3):328–passim. [PubMed] [Google Scholar]
  16. MAUMENEE A. E. Keratitis secondary to keratinization of the tarsal conjunctiva. Am J Ophthalmol. 1956 Mar;41(3):477–487. doi: 10.1016/0002-9394(56)91261-2. [DOI] [PubMed] [Google Scholar]
  17. MOSES C., LINN J. G., Jr, ALLEN A. J. Experimental production of radiation cataracts by fast neutrons. AMA Arch Ophthalmol. 1953 Nov;50(5):609–612. doi: 10.1001/archopht.1953.00920030619008. [DOI] [PubMed] [Google Scholar]
  18. Macfaul P. A., Bedford M. A. Ocular complications after therapeutic irradiation. Br J Ophthalmol. 1970 Apr;54(4):237–247. doi: 10.1136/bjo.54.4.237. [DOI] [PMC free article] [PubMed] [Google Scholar]

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