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. 1976 Jun;60(6):431–453. doi: 10.1136/bjo.60.6.431

Macular and perimacular vascular remodelling sickling haemoglobinopathies.

G K Asdourian, K C Nagpal, B Busse, M Goldbaum, D Patriankos, M F Rabb, M F Goldberg
PMCID: PMC1017523  PMID: 952816

Abstract

The posterior pole vasculature of 100 patients with different sickling haemoglobinopathies was studied prospectively over a period of three years. Various abnormalities of the posterior pole vasculature were seen in 29 per cent of the patients. Continuous remodelling of the macular and perimacular vasculature occurred. Visual acuity was variably affected and sometimes remained intact.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bresnick G. H., De Venecia G., Myers F. L., Harris J. A., Davis M. D. Retinal ischemia in diabetic retinopathy. Arch Ophthalmol. 1975 Dec;93(12):1300–1310. doi: 10.1001/archopht.1975.01010020934002. [DOI] [PubMed] [Google Scholar]
  2. Condon P. I., Serjeant G. R. Ocular findings in homozygous sickle cell anemia in Jamaica. Am J Ophthalmol. 1972 Apr;73(4):533–543. doi: 10.1016/0002-9394(72)90005-0. [DOI] [PubMed] [Google Scholar]
  3. Conrad W. C., Penner R. Sickle-cell trait and central retinal-artery occlusion. Am J Ophthalmol. 1967 Mar;63(3):465–468. doi: 10.1016/0002-9394(67)90245-0. [DOI] [PubMed] [Google Scholar]
  4. ESMANN V., LUNDBAEK K., MADSEN P. H. TYPES OF EXUDATES IN DIABETIC RETINOPATHY. Acta Med Scand. 1963 Sep;174:375–384. doi: 10.1111/j.0954-6820.1963.tb07936.x. [DOI] [PubMed] [Google Scholar]
  5. Galinos S. O., Asdourian G. K., Woolf M. B., Stevens T. S., Lee C. B., Goldberg M. F., Chow J. C., Busse B. J. Spontaneous remodeling of the peripheral retinal vasculature in sickling disorders. Am J Ophthalmol. 1975 May;79(5):853–870. doi: 10.1016/0002-9394(75)90747-3. [DOI] [PubMed] [Google Scholar]
  6. Galinos S., Rabb M. F., Goldberg M. F., Frenkel M. Hemoglobin SC disease and iris atrophy. Am J Ophthalmol. 1973 Mar;75(3):421–425. doi: 10.1016/0002-9394(73)91150-1. [DOI] [PubMed] [Google Scholar]
  7. Goldberg M. F. Natural history of untreated proliferative sickle retinopathy. Arch Ophthalmol. 1971 Apr;85(4):428–437. doi: 10.1001/archopht.1971.00990050430006. [DOI] [PubMed] [Google Scholar]
  8. Harnish A., Pearce M. L. Evolution of hypertensive retinal vascular disease: correlation between clinical and postmortem observations. Medicine (Baltimore) 1973 Nov;52(6):483–533. doi: 10.1097/00005792-197311000-00001. [DOI] [PubMed] [Google Scholar]
  9. KABAKOW B., VAN WEIMOKLY S. S., LYONS H. A. Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. AMA Arch Ophthalmol. 1955 Nov;54(5):670–676. [PubMed] [Google Scholar]
  10. KORNZWEIG A. L., ELIASOPH I., FELDSTEIN M. OCCLUSIVE DISEASE OF RETINAL VASCULATURE. A CLINICOPATHOLOGICAL STUDY. Arch Ophthalmol. 1964 Apr;71:542–551. doi: 10.1001/archopht.1964.00970010558021. [DOI] [PubMed] [Google Scholar]
  11. Knapp J. W. Isolated macular infarction in sickle cell (SS) disease. Am J Ophthalmol. 1972 Jun;73(6):857–859. doi: 10.1016/0002-9394(72)90452-7. [DOI] [PubMed] [Google Scholar]
  12. Kohner E. M. The effect of diabetes on retino-vascular function. Acta Diabetol Lat. 1971 Sep;8 (Suppl 1):135–178. [PubMed] [Google Scholar]
  13. Kuwabara T., Cogan D. G. Retinal vascular patterns. VII. Acellular change. Invest Ophthalmol. 1965 Dec;4(6):1049–1064. [PubMed] [Google Scholar]
  14. NOVOTNY H. R., ALVIS D. L. A method of photographing fluorescence in circulating blood in the human retina. Circulation. 1961 Jul;24:82–86. doi: 10.1161/01.cir.24.1.82. [DOI] [PubMed] [Google Scholar]
  15. PATON D. The conjunctival sign ox sickle-cell disease. Further observations. Arch Ophthalmol. 1962 Nov;68:627–632. doi: 10.1001/archopht.1962.00960030631010. [DOI] [PubMed] [Google Scholar]
  16. Ryan S. J., Jr Occlusion of the macular capillaries in sickle cell hemoglobin C disease. Am J Ophthalmol. 1974 Apr;77(4):459–461. doi: 10.1016/0002-9394(74)90454-1. [DOI] [PubMed] [Google Scholar]
  17. Stevens T. S., Busse B., Lee C. B., Woolf M. B., Galinos S. O., Goldberg M. F. Sickling hemoglobinopathies; macular and perimacular vascular abnormalities. Arch Ophthalmol. 1974 Dec;92(6):455–463. doi: 10.1001/archopht.1974.01010010469002. [DOI] [PubMed] [Google Scholar]
  18. Stockman J. A., Nigro M. A., Mishkin M. M., Oski F. A. Occlusion of large cerebral vessels in sickle-cell anemia. N Engl J Med. 1972 Oct 26;287(17):846–849. doi: 10.1056/NEJM197210262871703. [DOI] [PubMed] [Google Scholar]
  19. Vrabec F. The temporal raphe of the human retina. Am J Ophthalmol. 1966 Nov;62(5):926–938. doi: 10.1016/0002-9394(66)91920-9. [DOI] [PubMed] [Google Scholar]
  20. Welch R. B., Goldberg M. F. Sickle-cell hemoglobin and its relation to fundus abnormality. Arch Ophthalmol. 1966 Mar;75(3):353–362. doi: 10.1001/archopht.1966.00970050355008. [DOI] [PubMed] [Google Scholar]

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