Table 1.

Comparing LMW tau to Big tau

	LMW tau	Big tau
Exon structure	No 4a	4a (250 aa), 4a-L (355 aa)
Alternative splicing	2, 3, 10	2, 3 (10?)
Protein size (kDa)	45–60	90–110
Developmental expression	Embryonic to adult Change from 3R to 4R	Postnatal/adult 4R
Distribution	Most of CNS neurons Non-neuronal cells	PNS neurons Selective CNS regions
Function	MT dynamics, Axonal transport Plasticity	Mostly unknown Stability?
Pathology	Tauopathies	None or slow
Therapeutics	Antibodies, knockdown	Protective?

3R, 4R, MTBD exon 10.