Table 1.
Approach | Main thrust/techniques | Representative references |
---|---|---|
Screening Chemical Libraries | Identification of new compounds with anti-biofilm activity, alone or in combination | 51, 52, 55, 56 |
High throughput screening (HTS) | ||
Turbinmicin | Produced by the microbiome of a marine animal | 57, 58 |
Inhibits extracellular vesicle-delivered biofilm matrix | ||
EntV | Antifungal peptide produced by E. faecalis | 60 |
Drug Repurposing | Search for new therapeutic indications for existing drugs | 68 |
Screening Repurposing libraries | ||
Nanotechnology | Nanomaterials, nanoparticles or nanoantibiotics | 76, 78 |
Size of less than 100 nm in at least one of their three dimensions | ||
Potent anti-biofilm activity, including against mixed biofilms | ||
Othera | Antimicrobial peptides | 87–102 |
Targeting extracellular DNA | ||
Probiotics | ||
Hsp 90 inhibition | ||
Modulators of quorum-sensing | ||
Photodynamic therapy (PDT) | ||
Catheter locks | ||
Surface coatings | ||
Inhibition of dispersion |
this list is not all inclusive.