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. 1971 May;26(3):277–283. doi: 10.1136/thx.26.3.277

Viability of autologous fascia lata in heart valve replacements

J C R Lincoln 1,1, P A Riley 1, A Revignas 1, M Geens 1, D N Ross 1, J K Ross 1
PMCID: PMC1019082  PMID: 5089492

Abstract

A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P<0·001). The collagen bundles were grossly disorganized and separated, suggesting a breakdown of the cross-linkage in the tissue. Redundant connective tissue on the surface of the valve cusp became oedematous and contained many trapped cells. A pseudoendothelium was formed within 10 days. Incorporation of tritium-labelled thymidine in the nuclei of the fibroblasts showed a sixfold reduction over 9 to 12 weeks following implantation, suggesting a failure of metabolism in these cells. The suitability of fascia lata for human heart valve replacement is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREACA J. R., ALLEN M. S., Jr, MULLER W. H., Jr SUPERIOR VENA CAVA REPLACEMENT WITH AUTOGENOUS FASCIA: AN EXPERIMENTAL STUDY. Am Surg. 1965 Sep;31:610–613. [PubMed] [Google Scholar]
  2. Gilbert J. W., Jr, Mansour K., Sanders S., Gravanis M. B. Experimental reconstruction of the tricuspid valve with autologous fascia lata. Arch Surg. 1968 Jul;97(1):149–153. doi: 10.1001/archsurg.1968.01340010179025. [DOI] [PubMed] [Google Scholar]
  3. Ionescu M. I., Ross D. N., Deac R., Grimshaw V. A., Taylor S. H., Whitaker W., Wooler G. H. Autologous fascia lata for heart valve replacement. Thorax. 1970 Jan;25(1):46–56. doi: 10.1136/thx.25.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Ionescu M. I., Ross D. N. Heart-valve replacement with autologous fascia lata. Lancet. 1969 Aug 16;2(7616):335–338. doi: 10.1016/s0140-6736(69)92696-8. [DOI] [PubMed] [Google Scholar]
  5. Myers W. O., Miller D. R. Autogenous fascial aortic valves in dogs. J Thorac Cardiovasc Surg. 1969 Jun;57(6):805–811. [PubMed] [Google Scholar]
  6. Senning A. Fascia lata replacement of aortic valves. J Thorac Cardiovasc Surg. 1967 Oct;54(4):465–470. [PubMed] [Google Scholar]

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