Table 1.
Cohort details
| Trait | Population cohort | Mean age, years | Female, % | Sample size, n | Study participants, n | Control participants, n | PMID |
|---|---|---|---|---|---|---|---|
| BMI | GIANT/UK Biobank | 55.5/56.9* | 54.0/54.2* | 681,275 | 30124842 | ||
| WHR | GIANT/UK Biobank | 55.5/56.9* | 54.0/54.2* | 694,649 | 30239722 | ||
| Hypertension | UK Biobank | 56.9* | 54.2* | 463,010 | 54,358 | 408,652 | GWAS ID: ukb-b-12493a |
| T2D | DIAGRAM/GERA/UK Biobank | 54.1/63.3/56.9* | 50.1/59.0/54.2* | 655,666 | 61,714 | 593,952 | 30054458 |
| FG | MAGIC | 50.9 | 47.7 | 133,010 | 22885924 | ||
| CKD | CKDGen | 54.0 | 50.0 | 625,219 | 64,164 | 561,055 | 31152163 |
| UACR | CKDGen | 57.0 | 54.4 | 547,361 | 31511532 | ||
| MA | CKDGen | 57.0 | 53.0 | 54,116 | 54,116 | 26631737 | |
| eGFR creatinine | CKDGen | 54.0 | 50.0 | 567,460 | 31152163 |
All participants were of European descent. MAGIC, Meta-analyses of Glucose and Insulin-Related Traits Consortium; PMID, PubMed Identifier; WHR, waist-to-hip ratio.
*
Study-specific characteristics were not available for all UK Biobank data and were extrapolated from data available.
a
Output from Medical Research Council Integrative Epidemiology Unit GWAS pipeline analysis using Phesant-derived variables from UK Biobank, version 2 (https://doi.org/10.5523/bris.pnoat8cxo0u52p6ynfaekeigi). DIAGRAM, Diabetes Genetics Replication and Meta-analysis; GERA, Genetic Epidemiology Research on Aging; CKDGEN, Chronic Kidney Disease Genetics; MRC-IEU, Medical Research Council Integrative Epidemiology Unit.