Nucleic Acids Research, Volume 40, Issue 14, 1 August 2012, Pages 6520–6533, https://doi.org/10.1093/nar/gks343
The Editors were alerted in July 2022 about potential issues with Figures 6E and 7D as detailed below.
Figure 6E, PCAF panel: the bands pCDNAØ (0–6h), and the bands p27-K100R (0–6h) appear to be highly similar.
Figure 7D: a splice line is visible between bands 2 and 3 in the PCAF panel but is not visible in the p27 and Actin panels.
The Editors subsequently investigated and contacted the corresponding author, co-authors, and institution. Two co-authors acknowledged receipt but could not provide the original data.
The Editors reached the following conclusions:
Figure 6E: there are small differences in the shape and intensity of the bands. No splice line is visible. The Editors believe the image to be authentic.
Figure 7D: a very faint splice line is also visible in the p27 panel. The lack of background in the Actin panel may hide a similar splice line. While authors should have disclosed the splicing in the figure and its caption, the Editors believe that the results of the experiment are still valid.
In conclusion, while these issues may not affect the results or conclusion of the study, in the absence of original data, the Editors advise readers to examine Figures 6E and 7D with care.
Julian E. Sale, Barry L. Stoddard
Senior Executive Editors