Abstract
The effect of a fish oil enriched diet containing about 3 g of eicosapentaenoic acid was studied in 10 patients with aspirin intolerant asthma. Subjects were studied during six weeks on a control diet followed by six weeks on the fish oil diet in a single blind study design. They were asked to record their peak expiratory flow (PEF) twice daily, bronchodilator and steroid doses, and subjective ratings of pulmonary symptoms on diary cards. There were no significant changes in symptom scores over the six weeks of either the control diet or the fish oil diet. PEF values, however, were significantly lower during the fifth and sixth week of the fish oil diet than during the control diet (308 v 262 l/min week 5 and 306 v 256 l/min week 6). Bronchodilator usage was also greater during the fifth and sixth week of the fish oil diet than during the control period (12.0 v 7.4 and 13.0 v 7.4 puffs a day in weeks 5 and 6). This pilot study suggests that fish diets may have a deleterious effect on patients with aspirin intolerant asthma.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Burdon J. G., Juniper E. F., Killian K. J., Hargreave F. E., Campbell E. J. The perception of breathlessness in asthma. Am Rev Respir Dis. 1982 Nov;126(5):825–828. doi: 10.1164/arrd.1982.126.5.825. [DOI] [PubMed] [Google Scholar]
- Ford-Hutchinson A. W., Bray M. A., Doig M. V., Shipley M. E., Smith M. J. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature. 1980 Jul 17;286(5770):264–265. doi: 10.1038/286264a0. [DOI] [PubMed] [Google Scholar]
- Goodnight S. H., Jr, Harris W. S., Connor W. E. The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study. Blood. 1981 Nov;58(5):880–885. [PubMed] [Google Scholar]
- Kordansky D., Adkinson N. F., Jr, Norman P. S., Rosenthal R. R. Asthma improved by nonsteroidal anti-inflammatory drugs. Ann Intern Med. 1978 Apr;88(4):508–511. doi: 10.7326/0003-4819-88-4-508. [DOI] [PubMed] [Google Scholar]
- Lee T. H., Arm J. P. Prospects for modifying the allergic response by fish oil diets. Clin Allergy. 1986 Mar;16(2):89–100. doi: 10.1111/j.1365-2222.1986.tb00752.x. [DOI] [PubMed] [Google Scholar]
- Lee T. H., Austen K. F., Leitch A. G., Israel E., Robinson D. R., Lewis R. A., Corey E. J., Drazen J. M. The effects of a fish-oil-enriched diet on pulmonary mechanics during anaphylaxis. Am Rev Respir Dis. 1985 Dec;132(6):1204–1209. doi: 10.1164/arrd.1985.132.6.1204. [DOI] [PubMed] [Google Scholar]
- Lee T. H., Hoover R. L., Williams J. D., Sperling R. I., Ravalese J., 3rd, Spur B. W., Robinson D. R., Corey E. J., Lewis R. A., Austen K. F. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med. 1985 May 9;312(19):1217–1224. doi: 10.1056/NEJM198505093121903. [DOI] [PubMed] [Google Scholar]
- MacGlashan D. W., Jr, Schleimer R. P., Peters S. P., Schulman E. S., Adams G. K., 3rd, Newball H. H., Lichtenstein L. M. Generation of leukotrienes by purified human lung mast cells. J Clin Invest. 1982 Oct;70(4):747–751. doi: 10.1172/JCI110670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mathison D. A., Stevenson D. D. Hypersensitivity to nonsteroidal antiinflammatory drugs: indications and methods for oral challenges. J Allergy Clin Immunol. 1979 Dec;64(6 Pt 2):669–674. doi: 10.1016/0091-6749(79)90036-8. [DOI] [PubMed] [Google Scholar]
- Slepian I. K., Mathews K. P., McLean J. A. Aspirin-sensitive asthma. Chest. 1985 Mar;87(3):386–391. doi: 10.1378/chest.87.3.386. [DOI] [PubMed] [Google Scholar]
- Stechschulte D. J., Orange R. P., Austen K. F. Detection of slow reacting substance of anaphylaxis (SRS-A) in plasma of guinea pigs during anaphylaxis. J Immunol. 1973 Nov;111(5):1585–1589. [PubMed] [Google Scholar]
- Terano T., Salmon J. A., Moncada S. Biosynthesis and biological activity of leukotriene B5. Prostaglandins. 1984 Feb;27(2):217–232. doi: 10.1016/0090-6980(84)90075-3. [DOI] [PubMed] [Google Scholar]
- Weksler B. B., Pett S. B., Alonso D., Richter R. C., Stelzer P., Subramanian V., Tack-Goldman K., Gay W. A., Jr Differential inhibition by aspirin of vascular and platelet prostaglandin synthesis in atherosclerotic patients. N Engl J Med. 1983 Apr 7;308(14):800–805. doi: 10.1056/NEJM198304073081402. [DOI] [PubMed] [Google Scholar]