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. 1989 Jun;44(6):485–490. doi: 10.1136/thx.44.6.485

Vertical gradients of lung density in healthy supine men.

A B Millar 1, D M Denison 1
PMCID: PMC1020809  PMID: 2763259

Abstract

Computed tomography was used to determine the vertical gradient of physical density in peripheral lung tissue of 12 healthy supine subjects, at total lung capacity and residual volume. At total lung capacity the mean (SD) density of peripheral lung tissue at the level of the mid right atrium was 0.0715 (0.017) g/cm3 and the vertical gradient of density was slight. At residual volume the density of peripheral tissue at the same level was 0.272 (0.067) g/cm3 and the vertical density gradient was curvilinear and more pronounced. Predictions of the gradient at residual volume were made on the basis of the known compliance of the lung and measured effects were attributed to the action of gravity on blood vessel distensibility at total lung capacity. These predictions agreed closely with the actual density gradient measured at residual volume and provide a basis for forecasting the vertical density gradient that would exist in healthy lungs at any degree of inflation. Departure from these gradients would imply local abnormalities of lung compliance, distribution of mechanical stress, or distensibility of vessels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brudin L. H., Rhodes C. G., Valind S. O., Wollmer P., Hughes J. M. Regional lung density and blood volume in nonsmoking and smoking subjects measured by PET. J Appl Physiol (1985) 1987 Oct;63(4):1324–1334. doi: 10.1152/jappl.1987.63.4.1324. [DOI] [PubMed] [Google Scholar]
  2. Denison D. M., Morgan M. D., Millar A. B. Estimation of regional gas and tissue volumes of the lung in supine man using computed tomography. Thorax. 1986 Aug;41(8):620–628. doi: 10.1136/thx.41.8.620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Glazier J. B., Hughes J. M., Maloney J. E., West J. B. Vertical gradient of alveolar size in lungs of dogs frozen intact. J Appl Physiol. 1967 Nov;23(5):694–705. doi: 10.1152/jappl.1967.23.5.694. [DOI] [PubMed] [Google Scholar]
  4. HOWELL J. B., PERMUTT S., PROCTOR D. F., RILEY R. L. Effect of inflation of the lung on different parts of pulmonary vascular bed. J Appl Physiol. 1961 Jan;16:71–76. doi: 10.1152/jappl.1961.16.1.71. [DOI] [PubMed] [Google Scholar]
  5. Hedlund L. W., Vock P., Effmann E. L. Computed tomography of the lung. Densitometric studies. Radiol Clin North Am. 1983 Dec;21(4):775–788. [PubMed] [Google Scholar]
  6. Hedlund L. W., Vock P., Effmann E. L., Lischko M. M., Putman C. E. Hydrostatic pulmonary edema. An analysis of lung density changes by computed tomography. Invest Radiol. 1984 Jul-Aug;19(4):254–262. doi: 10.1097/00004424-198407000-00004. [DOI] [PubMed] [Google Scholar]
  7. Hoffman E. A. Effect of body orientation on regional lung expansion: a computed tomographic approach. J Appl Physiol (1985) 1985 Aug;59(2):468–480. doi: 10.1152/jappl.1985.59.2.468. [DOI] [PubMed] [Google Scholar]
  8. Huang H. K., Wu S. C. The evaluation of mass densities of human body in vivo from CT scans. Comput Biol Med. 1976 Oct;6(4):337–343. doi: 10.1016/0010-4825(76)90070-6. [DOI] [PubMed] [Google Scholar]
  9. Kaneko K., Milic-Emili J., Dolovich M. B., Dawson A., Bates D. V. Regional distribution of ventilation and perfusion as a function of body position. J Appl Physiol. 1966 May;21(3):767–777. doi: 10.1152/jappl.1966.21.3.767. [DOI] [PubMed] [Google Scholar]
  10. Kreel L. Computer tomography of the thorax. Radiol Clin North Am. 1978 Dec;16(3):575–584. [PubMed] [Google Scholar]
  11. Michels D. B., West J. B. Distribution of pulmonary ventilation and perfusion during short periods of weightlessness. J Appl Physiol Respir Environ Exerc Physiol. 1978 Dec;45(6):987–998. doi: 10.1152/jappl.1978.45.6.987. [DOI] [PubMed] [Google Scholar]
  12. Millar A. B., Fromson B., Strickland B. A., Denison D. M. Computed tomography based estimates of regional gas and tissue volume of the lung in supine subjects with chronic airflow limitation or fibrosing alveolitis. Thorax. 1986 Dec;41(12):932–939. doi: 10.1136/thx.41.12.932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mull R. T. Mass estimates by computed tomography: physical density from CT numbers. AJR Am J Roentgenol. 1984 Nov;143(5):1101–1104. doi: 10.2214/ajr.143.5.1101. [DOI] [PubMed] [Google Scholar]
  14. PERMUTT S., HOWELL J. B., PROCTOR D. F., RILEY R. L. Effect of lung inflation on static pressure-volume characteristics of pulmonary vessels. J Appl Physiol. 1961 Jan;16:64–70. doi: 10.1152/jappl.1961.16.1.64. [DOI] [PubMed] [Google Scholar]
  15. Robinson P. J., Kreel L. Pulmonary tissue attenuation with computed tomography: comparison of inspiration and expiration scans. J Comput Assist Tomogr. 1979 Dec;3(6):740–748. [PubMed] [Google Scholar]
  16. Rosenblum L. J., Mauceri R. A., Wellenstein D. E., Thomas F. D., Bassano D. A., Raasch B. N., Chamberlain C. C., Heitzman E. R. Density patterns in the normal lung as determined by computed tomography. Radiology. 1980 Nov;137(2):409–416. doi: 10.1148/radiology.137.2.7433674. [DOI] [PubMed] [Google Scholar]
  17. Singhal S., Henderson R., Horsfield K., Harding K., Cumming G. Morphometry of the human pulmonary arterial tree. Circ Res. 1973 Aug;33(2):190–197. doi: 10.1161/01.res.33.2.190. [DOI] [PubMed] [Google Scholar]
  18. Vock P., Salzmann C. Comparison of computed tomographic lung density with haemodynamic data of the pulmonary circulation. Clin Radiol. 1986 Sep;37(5):459–464. doi: 10.1016/s0009-9260(86)80054-x. [DOI] [PubMed] [Google Scholar]
  19. Wandtke J. C., Hyde R. W., Fahey P. J., Utell M. J., Plewes D. B., Goske M. J., Fischer H. W. Measurement of lung gas volume and regional density by computed tomography in dogs. Invest Radiol. 1986 Feb;21(2):108–117. doi: 10.1097/00004424-198602000-00005. [DOI] [PubMed] [Google Scholar]
  20. Wegener O. H., Koeppe P., Oeser H. Measurement of lung density by computed tomography. J Comput Assist Tomogr. 1978 Jul;2(3):263–273. doi: 10.1097/00004728-197807000-00003. [DOI] [PubMed] [Google Scholar]

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