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. 1989 Jun;44(6):513–515. doi: 10.1136/thx.44.6.513

Renal and pulmonary effects of angiotensin converting enzyme inhibition in chronic hypoxic lung disease.

R M Oliver 1, A J Peacock 1, J S Fleming 1, D G Waller 1
PMCID: PMC1020814  PMID: 2669225

Abstract

The effects of 28 days' treatment with captopril or with placebo on renal and pulmonary function were evaluated in nine patients with stable pulmonary heart disease. Captopril (25 mg twice daily) caused a 17% rise in effective renal plasma flow but no change in glomerular filtration rate, resulting in a fall in filtration fraction likely to favour natriuresis. Captopril did not alter FEV1, lung volumes, or arterial oxygen or carbon dioxide tension.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atlas S. A., Case D. B., Sealey J. E., Laragh J. H., McKinstry D. N. Interruption of the renin-angiotensin system in hypertensive patients by captopril induces sustained reduction in aldosterone secretion, potassium retention and natruiresis. Hypertension. 1979 May-Jun;1(3):274–280. doi: 10.1161/01.hyp.1.3.274. [DOI] [PubMed] [Google Scholar]
  2. DAVIES D. F., SHOCK N. W. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest. 1950 May;29(5):496–507. doi: 10.1172/JCI102286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Düsterdieck G., McElwee G. Estimation of angiotensin II concentration in human plasma by radioimmunoassay. Some applications to physiological and clinical states. Eur J Clin Invest. 1971 Nov;2(1):32–38. doi: 10.1111/j.1365-2362.1971.tb00565.x. [DOI] [PubMed] [Google Scholar]
  4. Farber M. O., Roberts L. R., Weinberger M. H., Robertson G. L., Fineberg N. S., Manfredi F. Abnormalities of sodium and H2O handling in chronic obstructive lung disease. Arch Intern Med. 1982 Jul;142(7):1326–1330. [PubMed] [Google Scholar]
  5. Farber M. O., Weinberger M. H., Robertson G. L., Fineberg N. S. The effects of angiotensin-converting enzyme inhibition on sodium handling in patients with advanced chronic obstructive pulmonary disease. Am Rev Respir Dis. 1987 Oct;136(4):862–866. doi: 10.1164/ajrccm/136.4.862. [DOI] [PubMed] [Google Scholar]
  6. HAMMOND J. D., MACKINNON J., SMITH W. D., STUART-HARRIS C. H. The renal circulation in chronic pulmonary disease and pulmonary heart failure. Q J Med. 1956 Jul;25(99):389–405. [PubMed] [Google Scholar]
  7. Kubo S., Nishioka A., Nishimura H., Kawamura K., Takatsu T. Effects of captopril on arterial and venous pressure, renal function, and humoral factors in severe chronic congestive heart failure. Clin Pharmacol Ther. 1984 Oct;36(4):456–463. doi: 10.1038/clpt.1984.204. [DOI] [PubMed] [Google Scholar]
  8. Tauxe W. N., Dubovsky E. V., Kidd T., Jr, Diaz F., Smith L. R. New formulas for the calculation of effective renal plasma flow. Eur J Nucl Med. 1982;7(2):51–54. doi: 10.1007/BF00251641. [DOI] [PubMed] [Google Scholar]
  9. Waller D. G., Keast C. M., Fleming J. S., Ackery D. M. Measurement of glomerular filtration rate with technetium-99m DTPA: comparison of plasma clearance techniques. J Nucl Med. 1987 Mar;28(3):372–377. [PubMed] [Google Scholar]

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