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. 1991 Nov;46(11):839–841. doi: 10.1136/thx.46.11.839

Treatment of pulmonary aspergilloma with itraconazole.

J H Campbell 1, J H Winter 1, M D Richardson 1, G S Shankland 1, S W Banham 1
PMCID: PMC1021040  PMID: 1663275

Abstract

In a 12 month open study of itraconazole in pulmonary aspergilloma nine patients received oral itraconazole 200 mg daily for six months followed by further itraconazole or observation for a further six months. There was no change in the serum IgG specific for Aspergillus fumigatus (mean (SE) change -4% (10%)) or symptoms of chronic cough and haemoptysis. In two of the three patients who continued treatment beyond six months symptoms and radiographic appearances improved and a temporary reduction in A fumigatus specific IgG occurred in one patient. Further experience of the effects of longer treatment are needed before oral itraconazole can be recommended for aspergilloma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hughes C. F., Waugh R., Lindsay D. Surgery for pulmonary aspergilloma: preoperative embolisation of the bronchial circulation. Thorax. 1986 Apr;41(4):324–325. doi: 10.1136/thx.41.4.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Jewkes J., Kay P. H., Paneth M., Citron K. M. Pulmonary aspergilloma: analysis of prognosis in relation to haemoptysis and survey of treatment. Thorax. 1983 Aug;38(8):572–578. doi: 10.1136/thx.38.8.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. MACPHERSON P. PULMONARY ASPERGILLOSIS IN ARGYLL. Br J Dis Chest. 1965 Jul;59:148–157. doi: 10.1016/s0007-0971(65)80005-5. [DOI] [PubMed] [Google Scholar]
  4. Richardson M. D., Stubbins J. M., Warnock D. W. Rapid enzyme-linked immunosorbent assay (ELISA) for Aspergillus fumigatus antibodies. J Clin Pathol. 1982 Oct;35(10):1134–1137. doi: 10.1136/jcp.35.10.1134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Richardson M. D., Turner A., Warnock D. W., Llewellyn P. A. Computer-assisted rapid enzyme-linked immunosorbent assay (ELISA) in the serological diagnosis of aspergillosis. J Immunol Methods. 1983 Jan 28;56(2):201–207. doi: 10.1016/0022-1759(83)90412-x. [DOI] [PubMed] [Google Scholar]
  6. Shale D. J., Faux J. A., Lane D. J. Trial of ketoconazole in non-invasive pulmonary aspergillosis. Thorax. 1987 Jan;42(1):26–31. doi: 10.1136/thx.42.1.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Shneerson J. M., Emerson P. A., Phillips R. H. Radiotherapy for massive haemoptysis from an aspergilloma. Thorax. 1980 Dec;35(12):953–954. doi: 10.1136/thx.35.12.953. [DOI] [PMC free article] [PubMed] [Google Scholar]

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