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. 1994 Mar;49(3):267–269. doi: 10.1136/thx.49.3.267

Effect of adding aminophylline infusion to nebulised salbutamol in severe acute asthma.

B M Zainudin 1, O Ismail 1, K Yusoff 1
PMCID: PMC1021158  PMID: 8202885

Abstract

BACKGROUND--The benefit of adding theophylline to beta 2 agonists in acute asthmatic attacks has been debated frequently. METHODS--In an open randomised study 25 patients with severe acute asthma who presented to the emergency department were treated with either a combined nebulised salbutamol (5 mg/dose) and aminophylline infusion (0.6-0.9 mg/kg/hour), or nebulised salbutamol alone. RESULTS--The responses to treatment as measured by peak expiratory flow (PEF) and the time taken to achieve maximum PEF were similar in both groups. Side effects were observed more commonly in patients receiving the combined treatment. CONCLUSIONS--Nebulised salbutamol is equally efficacious in acute asthma when given alone or in combination with aminophylline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bogaert M. G. Non-linear kinetics of theophylline. Eur J Respir Dis. 1984 Jan;65(1):1–3. [PubMed] [Google Scholar]
  2. Kelly H. W., Menendez R., Voyles W. Lack of significant arrhythmogenicity from chronic theophylline and beta-2-adrenergic combination therapy in asthmatic subjects. Ann Allergy. 1985 May;54(5):405–410. [PubMed] [Google Scholar]
  3. Littenberg B. Aminophylline treatment in severe, acute asthma. A meta-analysis. JAMA. 1988 Mar 18;259(11):1678–1684. [PubMed] [Google Scholar]
  4. Persson C. G. On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter. Thorax. 1985 Dec;40(12):881–886. doi: 10.1136/thx.40.12.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Rossing T. H., Fanta C. H., Goldstein D. H., Snapper J. R., McFadden E. R., Jr Emergency therapy of asthma: comparison of the acute effects of parenteral and inhaled sympathomimetics and infused aminophylline. Am Rev Respir Dis. 1980 Sep;122(3):365–371. doi: 10.1164/arrd.1980.122.3.365. [DOI] [PubMed] [Google Scholar]
  6. Rossing T. H., Fanta C. H., McFadden E. R., Jr A controlled trial of the use of single versus combined-drug therapy in the treatment of acute episodes of asthma. Am Rev Respir Dis. 1981 Feb;123(2):190–194. doi: 10.1164/arrd.1981.123.2.190. [DOI] [PubMed] [Google Scholar]
  7. Sessler C. N., Cohen M. D. Cardiac arrhythmias during theophylline toxicity. A prospective continuous electrocardiographic study. Chest. 1990 Sep;98(3):672–678. doi: 10.1378/chest.98.3.672. [DOI] [PubMed] [Google Scholar]
  8. Siegel D., Sheppard D., Gelb A., Weinberg P. F. Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. Am Rev Respir Dis. 1985 Aug;132(2):283–286. doi: 10.1164/arrd.1985.132.2.283. [DOI] [PubMed] [Google Scholar]
  9. Williams S. J., Parrish R. W., Seaton A. Comparison of intravenous aminophylline and salbutamol in severe asthma. Br Med J. 1975 Dec 20;4(5998):685–685. doi: 10.1136/bmj.4.5998.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Woodcock A. A., Johnson M. A., Geddes D. M. Theophylline prescribing, serum concentrations, and toxicity. Lancet. 1983 Sep 10;2(8350):610–613. doi: 10.1016/s0140-6736(83)90691-8. [DOI] [PubMed] [Google Scholar]

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