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. 1995 May;50(5):548–550. doi: 10.1136/thx.50.5.548

Recovery of Pseudomonas aeruginosa in respiratory specimens from HIV positive patients being evaluated for Pneumocystis carinii pneumonia.

R L Doyle 1, J J Doherty 1, L H Zimmerman 1
PMCID: PMC1021227  PMID: 7597670

Abstract

BACKGROUND--Despite the immune suppression, frequent hospital admissions, and many intercurrent illnesses associated with HIV infection, Pseudomonas aeruginosa has been cited relatively infrequently as a respiratory pathogen in HIV positive patients. METHODS--The microbiological isolates, medical records, radiographic reports, and laboratory data from 224 patients undergoing sputum induction and/or bronchoalveolar lavage for evaluation of respiratory symptoms suspicious for Pneumocystis carinii pneumonia (PCP) from 1989 to 1992 were reviewed retrospectively. RESULTS--An increasing number of respiratory isolates with Pseudomonas aeruginosa was found over this time period. Eighteen of the 224 patients were identified in whom P aeruginosa was recovered on at least one occasion. These patients were more likely to have a history of smoking and prior PCP than those in whom Pseudomonas was not recovered. Mean CD4 counts were also significantly lower in these patients. CONCLUSIONS--Pseudomonas aeruginosa may be recovered from a substantial number of respiratory isolates from HIV positive patients suspected of having PCP. The prevalence of this phenomenon may be increasing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Schiffman G., Abrams D., Volberding P., Ziegler J., Conant M. B-cell immunodeficiency in acquired immune deficiency syndrome. JAMA. 1984 Mar 16;251(11):1447–1449. [PubMed] [Google Scholar]
  2. Baron A. D., Hollander H. Pseudomonas aeruginosa bronchopulmonary infection in late human immunodeficiency virus disease. Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):992–996. doi: 10.1164/ajrccm/148.4_Pt_1.992. [DOI] [PubMed] [Google Scholar]
  3. Baron A. D., Hollander H. Pseudomonas aeruginosa bronchopulmonary infection in late human immunodeficiency virus disease. Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):992–996. doi: 10.1164/ajrccm/148.4_Pt_1.992. [DOI] [PubMed] [Google Scholar]
  4. Döring G., Obernesser H. J., Botzenhart K., Flehmig B., Høiby N., Hofmann A. Proteases of Pseudomonas aeruginosa in patients with cystic fibrosis. J Infect Dis. 1983 Apr;147(4):744–750. doi: 10.1093/infdis/147.4.744. [DOI] [PubMed] [Google Scholar]
  5. Graham N. M., Zeger S. L., Park L. P., Vermund S. H., Detels R., Rinaldo C. R., Phair J. P. The effects on survival of early treatment of human immunodeficiency virus infection. N Engl J Med. 1992 Apr 16;326(16):1037–1042. doi: 10.1056/NEJM199204163261601. [DOI] [PubMed] [Google Scholar]
  6. Kielhofner M., Atmar R. L., Hamill R. J., Musher D. M. Life-threatening Pseudomonas aeruginosa infections in patients with human immunodeficiency virus infection. Clin Infect Dis. 1992 Feb;14(2):403–411. doi: 10.1093/clinids/14.2.403. [DOI] [PubMed] [Google Scholar]
  7. Lemp G. F., Hirozawa A. M., Cohen J. B., Derish P. A., McKinney K. C., Hernandez S. R. Survival for women and men with AIDS. J Infect Dis. 1992 Jul;166(1):74–79. doi: 10.1093/infdis/166.1.74. [DOI] [PubMed] [Google Scholar]
  8. Rubin J. S., Honigberg R. Sinusitis in patients with the acquired immunodeficiency syndrome. Ear Nose Throat J. 1990 Jul;69(7):460–463. [PubMed] [Google Scholar]
  9. Small C. B., Kaufman A., Armenaka M., Rosenstreich D. L. Sinusitis and atopy in human immunodeficiency virus infection. J Infect Dis. 1993 Feb;167(2):283–290. doi: 10.1093/infdis/167.2.283. [DOI] [PubMed] [Google Scholar]
  10. Terpstra F. G., Al B. J., Roos M. T., De Wolf F., Goudsmit J., Schellekens P. T., Miedema F. Longitudinal study of leukocyte functions in homosexual men seroconverted for HIV: rapid and persistent loss of B cell function after HIV infection. Eur J Immunol. 1989 Apr;19(4):667–673. doi: 10.1002/eji.1830190415. [DOI] [PubMed] [Google Scholar]
  11. Tucker K. J., Anton B., Tucker H. J. The effect of human immunodeficiency virus infection on the distribution and outcome of pneumonia in intensive care units. West J Med. 1992 Dec;157(6):637–640. [PMC free article] [PubMed] [Google Scholar]
  12. Whimbey E., Gold J. W., Polsky B., Dryjanski J., Hawkins C., Blevins A., Brannon P., Kiehn T. E., Brown A. E., Armstrong D. Bacteremia and fungemia in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986 Apr;104(4):511–514. doi: 10.7326/0003-4819-104-4-511. [DOI] [PubMed] [Google Scholar]
  13. Witt D. J., Craven D. E., McCabe W. R. Bacterial infections in adult patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related complex. Am J Med. 1987 May;82(5):900–906. doi: 10.1016/0002-9343(87)90150-1. [DOI] [PubMed] [Google Scholar]

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