Abstract
BACKGROUND--Nebulised frusemide has been shown to be protective against bronchoconstricting stimuli in adult asthmatic subjects and against cold air challenge in children. Animal studies suggest that inhaled frusemide may be more effective in the young. METHODS--A double blind placebo, controlled, crossover study on the effect on exercise of pretreatment with frusemide (20 mg) from a metered dose inhaler via a large volume spacer (Volumatic) was performed in 12 asthmatic children. Exercise testing consisted of eight minutes of running on a treadmill in an environmentally controlled laboratory. RESULTS--Deterioration in lung function was less after frusemide than after the placebo exercise tests. The mean (95% CI) maximum percentage falls in forced expiratory volume in one second (FEV1) were 14.4% (7.7 to 21.0) for placebo and 5.7% (2.3 to 9.0) for frusemide. CONCLUSIONS--Inhaled frusemide via a metered dose inhaler reduces exercise-induced bronchoconstriction in children.
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Selected References
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- Bianco S., Pieroni M. G., Refini R. M., Rottoli L., Sestini P. Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions. N Engl J Med. 1989 Oct 19;321(16):1069–1073. doi: 10.1056/NEJM198910193211602. [DOI] [PubMed] [Google Scholar]
- Bianco S., Pieroni M. G., Refini R. M., Rottoli L., Sestini P. Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions. N Engl J Med. 1989 Oct 19;321(16):1069–1073. doi: 10.1056/NEJM198910193211602. [DOI] [PubMed] [Google Scholar]
- Bianco S., Vaghi A., Robuschi M., Pasargiklian M. Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet. 1988 Jul 30;2(8605):252–255. doi: 10.1016/s0140-6736(88)92540-8. [DOI] [PubMed] [Google Scholar]
- Nichol G. M., Alton E. W., Nix A., Geddes D. M., Chung K. F., Barnes P. J. Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis. 1990 Sep;142(3):576–580. doi: 10.1164/ajrccm/142.3.576. [DOI] [PubMed] [Google Scholar]
- Nichol G. M., Alton E. W., Nix A., Geddes D. M., Chung K. F., Barnes P. J. Effect of inhaled furosemide on metabisulfite- and methacholine-induced bronchoconstriction and nasal potential difference in asthmatic subjects. Am Rev Respir Dis. 1990 Sep;142(3):576–580. doi: 10.1164/ajrccm/142.3.576. [DOI] [PubMed] [Google Scholar]
- Pavord I. D., Wisniewski A., Tattersfield A. E. Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids. Thorax. 1992 Oct;47(10):797–800. doi: 10.1136/thx.47.10.797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Robuschi M., Gambaro G., Spagnotto S., Vaghi A., Bianco S. Inhaled frusemide is highly effective in preventing ultrasonically nebulised water bronchoconstriction. Pulm Pharmacol. 1989;1(4):187–191. doi: 10.1016/s0952-0600(89)80016-x. [DOI] [PubMed] [Google Scholar]
- Robuschi M., Gambaro G., Spagnotto S., Vaghi A., Bianco S. Inhaled frusemide is highly effective in preventing ultrasonically nebulised water bronchoconstriction. Pulm Pharmacol. 1989;1(4):187–191. doi: 10.1016/s0952-0600(89)80016-x. [DOI] [PubMed] [Google Scholar]
- Seidenberg J., Dehning J., von der Hardt H. Inhaled frusemide against cold air induced bronchoconstriction in asthmatic children. Arch Dis Child. 1992 Feb;67(2):214–217. doi: 10.1136/adc.67.2.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silverman M., Anderson S. D. Standardization of exercise tests in asthmatic children. Arch Dis Child. 1972 Dec;47(256):882–889. doi: 10.1136/adc.47.256.882. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stevens E. L., Uyehara C. F., Southgate W. M., Nakamura K. T. Furosemide differentially relaxes airway and vascular smooth muscle in fetal, newborn, and adult guinea pigs. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1192–1197. doi: 10.1164/ajrccm/146.5_Pt_1.1192. [DOI] [PubMed] [Google Scholar]