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. 1983 Mar;138(3):371–374.

Theophylline-Induced Seizures: Clinical and Pathophysiologic Aspects

Tsutomu Nakada, Ingrid L Kwee, Alfred M Lerner, Michael P Remler
PMCID: PMC1021471  PMID: 6858124

Abstract

The clinical features and management of theophylline-induced seizures are not well appreciated in spite of their unique aspects. These seizures tend to occur in neurologically intact patients and leave no or only minor neurologic sequelae if controlled early. They begin with focal motor seizures with or without secondary generalization and are followed by stupor or coma. They are responsive only to adjustment of theophylline dosage. Should the motor phenomenon persist, it takes the form of epilepsia partialis continua. Extensive workup for a structural brain lesion may be unrewarding. The electroencephalogram typically shows periodic lateralized epileptiform discharges, which may provide a diagnostic clue.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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