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Main roles of SMN protein in cells. SMN is essential for the assembly of spliceosomal snRNPs, which are necessary for the splicing and expression of mRNAs. A cascade of events occurs as a result of SMN deficiency. Specifically, Sm core formation is impaired, SnRNP levels are decreased, stasimon is disrupted, and critical neuronal functions are disrupted, ultimately resulting in SMA.
