Table 2.
The association of platelet 5-HT concentration and platelet MAO-B activity with clinical parameters of asthma patients.
| Clinical Parameters | Platelet 5-HT Concentration (nmol/mg Protein) |
Platelet MAO-B Activity (nmol/mg of Protein Per Hour) |
|
|---|---|---|---|
| Total Serum IgE (IU/mL) | p = 0.52; r = 0.06 | p = 0.66; r = 0.04 | Spearman correlation |
| Blood eosinophils (×109/L) | p = 0.63; r = 0.04 | p = 0.39; r = 0.08 | |
| Blood neutrophils (×109/L) | p = 0.52; r = 0.06 | p = 0.02; r = 0.21 | |
| FENO (ppb) | p = 0.99; r = −0.001 | p = 0.70; r = −0.04 | |
| FEV1 (% of predicted value) | p = 0.92; r = 0.01 | p = 0.60; r = 0.05 | |
| FVC (% of predicted value) | p = 0.28; r = 0.10 | p = 0.21; r = 0.11 | |
| PEF (% of predicted value) | p = 0.20; r = −0.12 | p = 0.73; r = −0.03 | |
| DLCO (%) | p = 0.20; r = −0.12 | p = 0.78; r = −0.03 | |
| Duration of disease (years) | p = 0.99; r = −0.001 | p = 0.63; r = 0.04 | |
| Comorbidities (N) | p = 0.88; r = −0.01 | p = 0.61; r = 0.05 | |
| Penicillin allergy | p = 0.28; U = 1018.0 | p = 0.86; U = 1159.0 | Mann-Whitney test |
| Nutritive allergy | p = 0.69; U = 602.0 | p = 0.43; U = 556.0 | |
| Animal dander/feather allergy | p = 0.71; U = 866.5 | p = 0.08; U = 678.0 | |
| Dust allergy | p = 0.66; U = 1676.0 | p = 0.12; U = 1469.0 | |
| Pollen allergy | p = 0.30; U = 1578.0 | p = 0.02; U = 1345.0 | |
| Fungal/mould allergy | p = 0.34; U = 401.50 | p = 0.86; U = 481.5 | |
| Early onset of asthma (age < 12 years) | p = 0.99; U = 1039.0 | p = 0.90; U = 1021.0 | |
| History of pneumonia | p = 0.77; U = 997.5 | p = 0.57; U = 957.5 | |
| Emergency intervention (ever) | p = 0.82; U = 1341.0 | p = 0.55; U = 1280.0 | |
| Hospitalization for asthma (ever) | p = 0.16; U = 1529.0 | p = 0.73; U = 1732.0 | |
| Nasal polyps | p = 0.38; U = 1104.0 | p = 0.62; U = 1164.0 | |
| Aspirin sensitivity | p = 0.27; U = 472.5 | p = 0.90; U = 580.0 | |
| Allergen specific immunotherapy | p = 0.89; U = 770.5 | p = 0.71; U = 740.0 | |
| Oral corticosteroid therapy | p = 0.59; U = 1262.0 | p = 0.09; U = 1067.0 | |
| Biological therapy | p = 0.08; U = 751.5 | p = 0.33; U = 860.5 |
DLCO = diffusing capacity of the lung for carbon monoxide; FeNO = fractional exhaled nitric oxide; FEV1 = forced expiratory volume in one second; FVC = forced vital capacity; IgE = immunoglobulin E; PEF = peak expiratory flow; ppb = parts per billion.