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. 2023 May 10;12(10):1353. doi: 10.3390/cells12101353

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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β-adrenergic receptor signaling regulates lipid metabolism and thermogenesis through PPAR nuclear hormone receptors. Following stimulation of the β-adrenergic receptor (AR) with catecholamines (CAs), a PKA–p38-Mapk-based signaling pathway induces the transcriptional coactivator Pgc-1α via phosphorylation. Pgc-1α promotes PPARα and PPARγ function in lipid catabolism, ketogenesis and Ucp1-mediated thermogenesis in mitochondria. FA, fatty acid; P, phosphate; p38 Mapk, p38 mitogen-activated protein kinase; PKA, protein kinase A; Pgc-1α, PPARγ coactivator-1α; PPARα, peroxisome proliferator-activated receptor-α; PPARγ, peroxisome proliferator-activated receptor-γ; Ucp1, uncoupling protein-1.